Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector74710.25692/ACEN.2021.2.7ReviewsОбзорыUnknownCertain aspects of brain tumor angiogenesisНекоторые аспекты ангиогенеза опухолей головного мозгаFrantsiyantsElena M.ФранциянцЕлена Михайловна
Russian Federation
esheiko@inbox.ruRostorguevEduard E.РосторгуевЭдуард Евгеньевич
Russian Federation
esheiko@inbox.ruSheikoElena A.ШейкоЕлена Александровна
Russian Federation
esheiko@inbox.ruRostov Research Institute of OncologyФГБУ «НМИЦ онкологии» Минздрава России17062021152505816062021Copyright ©; 2021, Frantsiyants E.M., Rostorguev E.E., Sheiko E.A.Copyright ©; 2021, Frantsiyants E.M., Rostorguev E.E., Sheiko E.A.2021Frantsiyants E.M., Rostorguev E.E., Sheiko E.A.Frantsiyants E.M., Rostorguev E.E., Sheiko E.A.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/747

Neuroepithelial tumors are one of the most common conditions with a high mortality rate. Despite the growing body of knowledge about the underlying biology of these tumors, their treatment has not changed significantly over the past decade.

Angiogenesis is a key component of the neoplastic process. Neoangiogenesis activity has a significant effect on tumor development and its metastatic potential. Studying how the growth and progression of gliomas are dependent on the degree of vascularisation has allowed the development of a new way of fighting tumors with antiangiogenesis therapy. Unfortunately, currently, antiangiogenesis therapy cannot cure a patient with glioma. The use of antiangiogenesis drugs to suppress tumor growth by inhibiting angiogenesis in gliomas is still limited despite being a promising direction. Information about molecular and genetic features of glial brain tumors, proangiogenic signalling pathways, mechanisms of angiogenesis, prognostic factors, etc., is essential to develop a new and effective therapy.

A recent literature review revealed quite contradictory data. On the one hand, neoangiogenesis of malignant brain tumors is considered to be an independent prognostic factor for glioma progression. However, some publications deny that angiogenesis in gliomas is a predictor of tumor development. All of the above underline the need for continued study into the relationship between angiogenesis and tumor growth.

Нейроэпитеальные опухоли головного мозга являются одной из распространённых патологий с высоким уровнем смертности. Несмотря на рост знаний об основополагающей биологии этих опухолей, их лечение за последнее десятилетие существенно не изменилось.

Одним из ключевых компонентов опухолевого процесса является ангиогенез. Активность неоангиогенеза оказывает существенное влияние на прогрессию опухоли и её метастатический потенциал. Изучение зависимости роста и прогрессии глиом от степени васкуляризации позволило разработать новый подход для борьбы с опухолями — противоангиогенную терапию. К сожалению, на современном этапе противоангиогенная терапия не приводит к излечению больных с глиомами. Использование антиангиогенных препаратов с целью подавления опухолевого роста путём ингибирования ангиогенеза у глиом, несмотря на свою перспективность, до сих пор ограничено. Информация о молекулярно-генетических особенностях глиальных опухолей головного мозга, проангиогенных сигнальных путей, механизмов ангиогенеза, прогностических факторов и др. в них чрезвычайно важна для разработки новой эффективной терапии.

Анализ современной литературы выявил существование достаточно противоречивых данных. С одной стороны, неоангиогез злокачественных опухолей мозга оценивается как независимый прогностический фактор прогрессии глиомы. Однако существуют публикации, отрицающие роль ангиогенеза в глиоме как предиктора развития опухоли. Все вышеперечисленное свидетельствует о необходимости продолжения изучения путей взаимосвязи ангиогенеза и опухолевого роста.

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