Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector8010.17816/psaic80ReviewsОбзорыUnknownEndogenous retrovirus: from fundamental studies to etiotropic therapy of multiple sclerosisЭндогенные ретровирусы: от фундаментальных исследований к этиотропной терапии рассеянного склерозаZakharovaMaria N.ЗахароваМария Николаевна
Russian Federation
bakulin@neurology.ruLogunovD. Y.ЛогуновД. Ю.
Russian Federation
bakulin@neurology.ruKocherginI. A.КочергинИ. A.
Russian Federation
bakulin@neurology.ruhttps://orcid.org/0000-0003-0716-3737BakulinIlya S.БакулинИлья Сергеевич
Russian Federation

Cand. Sci. (Med.), researcher, Department of neurorehabilitation and physiotherapy

к.м.н., н.с. отд. нейрореабилитации и физиотерапии

bakulin@neurology.ruResearch Center of NeurologyФГБНУ «Научный центр неврологии»N.F. Gamaleya Research Institute of Epidemiology and MicrobiologyФГБУ «Федеральный научно-исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи»0712201594495331012017Copyright ©; 2015, Zakharova M.N., Logunov D.Y., Kochergin I.A., Bakulin I.S.Copyright ©; 2015, Zakharova M.N., Logunov D.Y., Kochergin I.A., Bakulin I.S.2015Zakharova M.N., Logunov D.Y., Kochergin I.A., Bakulin I.S.Zakharova M.N., Logunov D.Y., Kochergin I.A., Bakulin I.S.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/80

Retroviruses are a single-stranded RNA viruses that introduce their genes into host cells genome. Genes of retroviruses compose 9.3% of human genome. These genes may influence human genome activity by changing its structure and stability, introducing regulatory elements and expression of retroviral genes. Recently role of endogen retroviruses in human disease is studied. This article presents an overview of the role of retroviruses in the development of multiple sclerosis and potential approaches to etiotropic therapy.

Ретровирусы – это РНК-содержащие вирусы, встраивающие свой геном в геном клетки организма хозяина. Гены ретровирусов составляют 9,3% генома человека и могут влиять на его функционирование за счет изменения структуры и стабильности локусов, привнесения новых регуляторных элементов, а также через экспрессию ретровирусных генов. В настоящее время активно изучается функциональная роль эндогенных ретровирусов в норме и при различных заболеваниях. В статье отражены современные представления о роли ретровирусов в развитии рассеянного склероза и открывающиеся в связи с этим перспективы этиотропной терапии.

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