Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector8210.17816/psaic82Original articlesОригинальные статьиUnknownThe range of neurological syndromes associated with glutamic acid decarboxylase antibodiesСпектр неврологических синдромов, ассоциированных с антителами к глутамат-декарбоксилазеKrasnovM. Yu.КрасновМаксим Юрьевич
Russian Federation
merritt.kraut@gmail.comPavlovE. V.ПавловЭ. В.
Russian Federation
merritt.kraut@gmail.comErshovaMargarita V.ЕршоваМаргарита Владимировна
Russian Federation
merritt.kraut@gmail.comTimerbaevaSofiya L.ТимербаеваСофия Л.
Russian Federation
merritt.kraut@gmail.comhttps://orcid.org/0000-0002-2704-6282IllarioshkinSergey N.ИллариошкинСергей Николаевич
Russian Federation

D. Sci. (Med.), Prof., Corr. Member of the Russian Academy of Sciences, Deputy Director, Head, Department for brain research

д.м.н., проф., член-корр. РАН, зам. директора по научной работе, рук. отдела исследований мозга

merritt.kraut@gmail.comResearch Center of NeurologyФГБНУ «Научный центр неврологии»0712201594374131012017Copyright ©; 2015, Krasnov M.Y., Pavlov E.V., Ershova M.V., Timerbaeva S.L., Illarioshkin S.N.Copyright ©; 2015, Krasnov M.Y., Pavlov E.V., Ershova M.V., Timerbaeva S.L., Illarioshkin S.N.2015Krasnov M.Y., Pavlov E.V., Ershova M.V., Timerbaeva S.L., Illarioshkin S.N.Krasnov M.Y., Pavlov E.V., Ershova M.V., Timerbaeva S.L., Illarioshkin S.N.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/82

Neurological syndromes caused by production of antibodies to glutamic acid decarboxylase (GAD65) are a relatively new area of modern clinical neurology, which is of great theoretical and practical interest. High titer of identified antibodies is a not always specific, but highly sensitive, marker for autoimmune CNS disorders. The authors present their own clinical observations and an analysis of the literature on a wide phenotypic range of GAD65-associated pathologies.

Неврологические синдромы, обусловленные продукцией антител к глутамат-декарбоксилазе (GAD65) – сравнительно новая область современной клинической неврологии, вызывающая большой интерес с теоретических и практических позиций. Высокий титр выявляемых антител является не всегда специфичным, но при этом высокочувствительным маркером аутоиммунного поражения ЦНС. Представлены собственные клинические наблюдения и анализ литературы, посвященной широкому фенотипическому спектру GAD65-ассоциированных форм патологии.

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