Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector86810.54101/ACEN.2023.4.9ReviewsОбзорыReview ArticleNeurobehavioral Testing as Cognitive Function Evaluation tool in Experimentally Induced Neurodegeneration in MiceНейроповеденческое тестирование как инструмент оценки когнитивных функций при экспериментальной нейродегенерации у мышейhttps://orcid.org/0000-0002-8675-3489PaninaYulia A.ПанинаЮлия Анатольевна
Russian Federation

Cand. Sci. (Med.), Associate Professor, Department of Biological Chemistry with Courses in Medical, Pharmaceutical and Toxicological Chemistry; Researcher, Research Institute of Molecular Medicine and Pathobiochemistry

к.м.н., доцент каф. биологической химии с курсом медицинской, фармацевтической и токсикологической химии, н.с. НИИ молекулярной медицины и патобиохимии

yulia.panina@list.ruhttps://orcid.org/0000-0002-7884-2721LopatinaOlga L.ЛопатинаОльга Леонидовна
Russian Federation

D. Sci. (Biol.), Associate Professor; Professor, Department of Biological Chemistry with Courses in Medical, Pharmaceutical and Toxicological Chemistry, Head of Social Neuroscience Laboratory

д.б.н., доцент, профессор каф. биологической химии с курсом медицинской, фармацевтической и токсикологической химии, руководитель лаборатории социальных нейронаук

ol.lopatina@gmail.comhttps://orcid.org/0000-0002-7344-7925MosyaginaAngelina I.МосягинаАнгелина Ивановна
Russian Federation

Junior Researcher, Research Institute of Molecular Medicine and Pathobiochemistry

м.н.с. НИИ молекулярной медицины и патобиохимии

angelina.mosiagina@gmail.comhttps://orcid.org/0000-0001-5742-8356KomlevaYulia K.КомлеваЮлия Константиновна
Russian Federation

D. Sci. (Med.), Associate Professor; Professor, Department of Biological Chemistry with Courses in Medical, Pharmaceutical and Toxicological Chemistry

д.м.н., доцент, профессор каф. биологической химии с курсами медицинской, фармацевтической и токсикологической химии

yuliakomleva@mail.ruhttps://orcid.org/0000-0002-9644-5500MorgunAndrey V.МоргунАндрей Васильевич
Russian Federation

D. Sci. (Med.), Head, Department of Outpatient Pediatrics and Propaedeutics of Childhood Diseases with a PE-Course

д.м.н., зав. каф. поликлинической педиатрии и пропедевтики детских болезней с курсом ПО

441682@mail.ruhttps://orcid.org/0000-0002-3341-1557GorinaYana V.ГоринаЯна Валерьевна
Russian Federation

D. Sci. (Biol.), Associate Professor; Associate Professor, Department of Biological Chemistry with Courses in Medical, Pharmaceutical and Toxicological Chemistry, Senior Researcher, Social Neuroscience Laboratory

д.б.н., доцент, доцент каф. биологической химии с курсами медицинской, фармацевтической и токсикологической химии, с.н.с. лаборатории социальных нейронаук

yana_20@bk.ruhttps://orcid.org/0000-0002-9718-1260HilazhevaElena D.ХилажеваЕлена Дмитриевна
Russian Federation

Senior Lecturer, Department of Biological Chemistry with Courses in Medical, Pharmaceutical and Toxicological Chemistry; Researcher, Research Institute of Molecular Medicine and Pathobiochemistry

старший преподаватель каф. биологической химии с курсами медицинской, фармацевтической и токсикологической химии, н.с. НИИ молекулярной медицины и патобиохимии

elena.hilazheva@mail.ruProf. V.F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого»2512202317472811507202228022023Copyright ©; 2023, Panina Y.A., Lopatina O.L., Mosyagina A.I., Komleva Y.K., Morgun A.V., Gorina Y.V., Hilazheva E.D.Copyright ©; 2023, Панина Ю.А., Лопатина О.Л., Мосягина А.И., Комлева Ю.К., Моргун А.В., Горина Я.В., Хилажева Е.Д.2023Panina Y.A., Lopatina O.L., Mosyagina A.I., Komleva Y.K., Morgun A.V., Gorina Y.V., Hilazheva E.D.Панина Ю.А., Лопатина О.Л., Мосягина А.И., Комлева Ю.К., Моргун А.В., Горина Я.В., Хилажева Е.Д.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/868

Neurodegeneration is a complex and multifactorial process presenting one of the major issues of fundamental science and clinical medicine due to its high prevalence, multiple nosological entities, and variations in pathogenesis. Translational research contributes to the study of neurodegenerative diseases, with modeling of such pathologies being an important part of this research. Behavioral testing in various animal models of neurodegenerative diseases allows to assess the model validity and reliability, as well as to investigate the potential efficacy of pharmacotherapy and other management approaches. In this overview we present test batteries that evaluate behavior, cognitive performance, and emotional states in animals with experimentally induced neurodegeneration.

Нейродегенерация — это сложный и многофакторный процесс, являющийся одной из серьёзных проблем фундаментальной науки и клинической медицины ввиду распространённости, множества нозологических форм и вариаций патогенетических механизмов. Трансляционные исследования способствуют изучению нейродегенеративных заболеваний, а немаловажной частью данного процесса является моделирование патологий. Поведенческое тестирование животных с различными моделями нейродегенеративных заболеваний позволяет оценить степень достоверности моделирования, а также рассмотреть эффективность потенциальной лекарственной терапии и других типов коррекции. В данном обзоре представлена подборка батареи тестов, применяемых для оценки поведения, когнитивных функций, эмоционального статуса у животных с экспериментальной нейродегенерацией.

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