Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector87010.54101/ACEN.2022.4.9TechnologiesТехнологииReview ArticleTheta-gamma phase-amplitude coupling: physiological basics, analysis methods, and perspectives of translation into clinical practiceФазово-амплитудное тета-гамма сопряжение: физиологические основы, методы анализа и перспективы трансляции в клиническую практикуhttps://orcid.org/0000-0003-1841-1177PoydashevaAlexandra G.ПойдашеваАлександра Георгиевна
Russian Federation

junior researcher, neurologist of Non-invasive neuromodulation group, Institute of Neurorehabilitation

м.н.с., врач-невролог группы неинвазивной нейромодуляции Института нейрореабилитации и восстановительной медицины

alexandra.poydasheva@gmail.comhttps://orcid.org/0000-0003-0716-3737BakulinIlya S.БакулинИлья Сергеевич
Russian Federation

Cand. Sci. (Med.), researcher, Head, Non-invasive neuro- modulation group, Institute of Neurorehabilitation

к.м.н., н.с., рук. группы неинвазивной нейромодуляции Института нейрореабилитации и восстановительной медицины

bakulinilya@gmail.comhttps://orcid.org/0000-0001-9951-9803SinitsynDmitry O.СиницынДмитрий Олегович
Russian Federation

Cand. Sci. (Phys.-Math.), senior researcher, research engineer, Group of consciousness and memory studies, Institute of Neurorehabilitation

к.ф.-м.н., с.н.с., инженер-исследователь группы исследований сознания и памяти Института нейрореабилитации и восстановительной медицины

d_sinitsyn@mail.ruhttps://orcid.org/0000-0001-8544-3107ZabirovaAlfiya H.ЗабироваАльфия Ходжаевна
Russian Federation

postgraduate student, Non-invasive neuromodulation group, Institute of Neurorehabilitation, neurologist

аспирант группы неинвазивной нейромодуляции Института нейрореабилитации и восстановительной медицины, врач-невролог

alfijasabirowa@gmail.comhttps://orcid.org/0000-0002-9267-8315LagodaDmitry Yu.ЛагодаДмитрий Юрьевич
Russian Federation

Cand. Sci. (Med.), junior researcher, Non-invasive neuromodulation group, Institute of Neurorehabilitation

к.м.н., м.н.с. группы неинвазивной нейромодуляции Института нейрореабилитации и восстановительной медицины

dmitrylagoda.doc@gmail.comhttps://orcid.org/0000-0003-3956-6362SuponevaNatalia A.СупоневаНаталья Александровна
Russian Federation

D. Sci. (Med.), Corresponding Member of RAS, Director. Institute of Neurorehabilitation

д.м.н., член-корреспондент РАН, директор Института нейрореабилитации и восстановительной медицины

nasu2709@mail.ruhttps://orcid.org/0000-0002-6338-0392PiradovMichael A.ПирадовМихаил Александрович
Russian Federation

D. Sci (Med.), Prof., Academician of RAS, Director

д.м.н., профессор, академик РАН, директор

mpi711@gmail.comResearch Center of NeurologyФГБНУ «Научный центр неврологии»2312202216471792707202225082022Copyright ©; 2022, Poydasheva A.G., Bakulin I.S., Sinitsyn D.O., Zabirova A.H., Lagoda D.Y., Suponeva N.A., Piradov M.A.Copyright ©; 2022, Пойдашева А.Г., Бакулин И.С., Синицын Д.О., Забирова А.Х., Лагода Д.Ю., Супонева Н.А., Пирадов М.А.2022Poydasheva A.G., Bakulin I.S., Sinitsyn D.O., Zabirova A.H., Lagoda D.Y., Suponeva N.A., Piradov M.A.Пойдашева А.Г., Бакулин И.С., Синицын Д.О., Забирова А.Х., Лагода Д.Ю., Супонева Н.А., Пирадов М.А.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/870

Studying rhythmic neural synchronization (cross-frequency coupling in various ranges) is an emerging topic in present-day neurophysiology. One of the best-studied cross-frequency couplings is theta-gamma phase-amplitude coupling that contributes to the cognitive function and may vary in patients with several conditions associated with cognitive impairment. Changes in theta-gamma coupling can be registered in a wide range of diseases associated with cognitive decline.

The review covers the physiological basics of theta-gamma coupling, its registration and calculation, correlation with cognitive test results in healthy volunteers, and changes in patients. We have discussed the results of the preliminary studies of frequency-dependent non-invasive brain stimulation based on theta-gamma coupling.

Исследование синхронизации ритмических осцилляций нейронов (кросс-частотное сопряжение в разных диапазонах) является интенсивно развивающимся направлением современной нейрофизиологии. Одним из наиболее изученных вариантов кросс-частотного сопряжения является фазово- амплитудное тета-гамма-сопряжение. Оно играет важную роль в реализации когнитивных функций и может изменяться при ряде патологических состояний, сопровождающихся развитием когнитивных нарушений.

В обзоре рассмотрены основные физиологические основы тета-гамма-сопряжения, методы его регистрации и расчёта, корреляция с показателями когнитивных тестов у здоровых добровольцев и изменения при патологии. Обсуждаются результаты предварительных исследований частотно- зависимой неинвазивной стимуляции головного мозга, основанной на тета-гамма-сопряжении.

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