Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector93310.54101/ACEN.2023.1.8TechnologiesТехнологииResearch ArticleMicroRNA detection in carotid atherosclerosis: prospects for clinical useОпределение микроРНК при каротидном атеросклерозе: перспективы клинического примененияhttps://orcid.org/0000-0002-5883-8119TanashyanМarine М.ТанашянМаринэ Мовсесовна
Russian Federation

D. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Deputy Director for Research, Head, 1st Neurological Department, Research Center of Neurology

д.м.н., профессор, член-корреспондент РАН, заместитель директора по научной работе, руководитель 1-го неврологического отделения ФГБНУ НЦН

mtanashyan@neurology.ruhttps://orcid.org/0000-0003-0522-767XRakurazhevAnton A.РаскуражевАнтон Алексеевич
Russian Federation

Cand. Sci. (Med.), Neurologist, Senior Researcher, 1st Neurological Department, Research Center of Neurology

к.м.н., врач-невролог, с.н.с. 1-го неврологического отделения ФГБНУ НЦН

rasckey@live.comhttps://orcid.org/0000-0002-4626-6520KuznetsovaPolina I.КузнецоваПолина Игоревна
Russian Federation

Cand. Sci. (Med.), Neurologist, Researcher, 1st Neurological Department, Research Center of Neurology

к.м.н., врач-невролог, н.с. 1-го неврологического отделения ФГБНУ НЦН

angioneurology0@gmail.comhttps://orcid.org/0000-0001-8960-721XMazurAndrew S.МазурАндрей Сергеевич
Russian Federation

Postgraduate Student, 1st Neurological Department, Research Center of Neurology

аспирант 1-го неврологического отделения ФГБНУ НЦН

a1699466@yandex.ruhttps://orcid.org/0000-0001-9604-7775ShabalinaАlla A.ШабалинаАлла Анатольевна
Russian Federation

D. Sci. (Med.), Leading Researcher, Head, Laboratory of Hemorheology, Hemostasis and Pharmacokinetics (with Clinical Laboratory Diagnostics), Research Center of Neurology

д.м.н., в.н.с., рук. лаб. гемореологии, гемостаза и фармакокинетики (с клинической лабораторной диагностикой) ФГБНУ НЦН

ashabalina@yandex.ruResearch Center of NeurologyФГБНУ «Научный центр неврологии»2903202317169741701202320012023Copyright ©; 2023, Tanashyan М.М., Rakurazhev A.A., Kuznetsova P.I., Mazur A.S., Shabalina А.A.Copyright ©; 2023, Танашян М.М., Раскуражев А.А., Кузнецова П.И., Мазур А.С., Шабалина А.А.2023Tanashyan М.М., Rakurazhev A.A., Kuznetsova P.I., Mazur A.S., Shabalina А.A.Танашян М.М., Раскуражев А.А., Кузнецова П.И., Мазур А.С., Шабалина А.А.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/933

Carotid atherosclerosis is a significant cause of cerebrovascular disease. However, with many candidate markers, precise assessment of its development and progression risks is still limited. This paper reviews state-of-the-art concepts of microRNA as an atherogenesis biomarker throughout various stages including endothelial dysfunction, cholesterol/lipid metabolism, inflammation, oxidative stress, angiogenesis regulation, and proliferation and migration of vascular smooth muscle cells. Based on the available literature, we have described most significant microRNAs for each stage characterized in brief. We have visualized interactions between microRNAs and validated target genes with MIENTURNET and suggest and justify a set of microRNAs for further pilot studies of carotid atherosclerosis.

Каротидный атеросклероз является значимой причиной ишемических цереброваскулярных заболеваний, однако возможности прецизионной оценки риска его развития и прогрессирования, несмотря на обилие предлагаемых маркеров, остаются ограниченными. В настоящей работе приводится обзор современных представлений о микроРНК в качестве биомаркеров атерогенеза на разных его этапах: эндотелиальная дисфункция, метаболизм холестерина/липидов, воспаление, оксидативный стресс, регуляция ангиогенеза, пролиферация и миграция гладкомышечных клеток сосудов. Для каждого из звеньев атерогенеза на основании данных литературы описаны наиболее значимые микроРНК, приведена их краткая характеристика. С помощью инструмента MIENTURNET визуализированы взаимодействия между микроРНК и валидированными таргетными генами. Предлагается и обосновывается набор микроРНК для дальнейших поисковых исследований каротидного атеросклероза.

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