Рассеянный склероз: современная концепция патогенеза и патогенетического лечения

I. A. Zavalishin1, А. V. Peresedova1
1НИИ неврологии РАМН, г. Москва, Россия

Аннотация


Концепция патогенеза рассеянного склероза в настоящее время включает выделение начальной воспалительной фазы, сопровождающейся фазой демиелинизации, а затем фазой нейродегенерации. В статье рассматриваются механизмы иммуновоспалительных реакций и аксонального повреждения при рассеянном склерозе. Определяющая роль иммунной системы в патогенезе заболевания определяет терапевтические подходы. Иммунологические эффекты глюкокортикостероидов обусловливают их положительное влияние при обострении болезни. Для длительной терапии, модулирующей течение рассеянного склероза, широко используются две группы препаратов (интерфероны бета и глатирамера ацетат). Назначение цитостатических препаратов и иммуноглобулинов при данном заболевании также определяется их иммуномодулирующими эффектами. Обсуждаются перспективы патогенетической терапии рассеянного склероза.

Ключевые слова

рассеянный склероз; патогенез; лечение

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Литература

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