Optical coherent tomography capabilities in the diagnosis of demyelinating diseases of the central nervous system

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Abstract

Optical coherence tomography (OCT) is a non-invasive technique routinely used for obtaining in vivo transverse images of tissues. In the field of neurology, OCT is used to assess retinal changes in various diseases, including multiple sclerosis, opticomyelitis, and opticomyelitis-associated disorders. In these demyelinating diseases, the pathological process involves not only the optic nerve itself, but also the retinal ganglion cells and their axons, the so-called retinal ganglionic complex, as well as the retinal nerve fiber layer. In the last decade, OCT as the method capable of assessing changes in the above-mentioned retinal layers has been applied as a highly sensitive technology for estimation of neurodegenerative process. The article discusses the possible use of OCT for differential diagnosis of demyelinating diseases of the central nervous system, as well as its application as a method for monitoring involvement of the nervous tissue in demyelinating diseases.

About the authors

Natalia V. Polekhina

Research Center of Neurology

Author for correspondence.
Email: natalie.polekhina@gmail.com
Russian Federation, Moscow

Zoya V. Surnina

Research Institute of Eye Diseases

Email: natalie.polekhina@gmail.com
Russian Federation, Moscow

Maria N. Zakharova

Research Center of Neurology

Email: natalie.polekhina@gmail.com
Russian Federation, Moscow

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Copyright (c) 2018 Polekhina N.V., Surnina Z.V., Zakharova M.N.

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