Hemorheology and hemostasis in ischemic stroke patients treated with i.v. thrombolysis

Abstract

Hemostatic and hemorheological dysregulations are the typical pathological conditions in stroke. Thorough dynamic examinations of hemostasis, platelet aggregation, kinetics of erythrocyte aggregation/disaggregation along with clinical and neuroimaging features and functional outcome were conducted in ischemic stroke patients who underwent i.v. thrombolysis or did not received rtPA. Increased strength of erythrocyte aggregates (SEA) was associated with better functional outcome, and that correlation was stronger in patients treated with i.v. thrombolysis.
Increased SEA was also associated with regression of ischemic lesion on DWI-MRI on Day 3 day in patients treated with i.v. thrombolysis.

About the authors

M. E. Gafarova

Research Center of Neurology (Moscow)

Author for correspondence.
Email: platonova@neurology.ru
Russian Federation

M. A. Domashenko

Research Center of Neurology (Moscow)

Email: platonova@neurology.ru
Russian Federation

D. Z. Korobkova

Research Center of Neurology (Moscow)

Email: platonova@neurology.ru
Russian Federation

M. Yu. Maximova

Research Center of Neurology (Moscow)

Email: platonova@neurology.ru
Russian Federation

M. A. Loskutnikov

Research Center of Neurology (Moscow)

Email: platonova@neurology.ru
Russian Federation

A. A. Shabalina

Research Center of Neurology (Moscow)

Email: platonova@neurology.ru
Russian Federation

M. V. Kostyreva

Research Center of Neurology (Moscow)

Email: platonova@neurology.ru
Russian Federation

R. N. Konovalov

Research Center of Neurology (Moscow)

Email: platonova@neurology.ru
Russian Federation

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Copyright (c) 2017 Gafarova M.E., Domashenko M.A., Korobkova D.Z., Maximova M.Y., Loskutnikov M.A., Shabalina A.A., Kostyreva M.V., Konovalov R.N.

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