Antiamnestic effect of dicholine succinate on models of amnesia caused by using scopolamine or electric irritation

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Abstract

We studied antiamnestic properties of dicholine succinate on models of amnesia caused by using scopolamine or electric irritation in the test of conditional reflex of passive avoidance. The experiments were carried out on outbreed male rats. It was shown that sub-chronic introduction of dicholine succinate in the dose of 25 mg/kg per day was characterized by a significant antiamnestic effect. The effect of dicholine succinate in amnesia caused by electric irritation was greater compared to that in the amnesia model caused by scopolamine.

About the authors

A. K. Sariev

Research Center of Neurology RAMS

Author for correspondence.
Email: platonova@neurology.ru
Russian Federation

V. M. Rychikhin

V.V. Zakusov Institute of Pharmacology RAMS (Moscow)

Email: platonova@neurology.ru
Russian Federation

D. A. Abaimov

Research Center of Neurology RAMS

Email: platonova@neurology.ru
Russian Federation

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Copyright (c) 2014 Sariev A.K., Rychikhin V.M., Abaimov D.A.

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