Organization of language network in healthy subjects and its reorganization in patients with poststroke aphasia

Cover Page


Cite item

Abstract

It’s a traditional belief among neuroscientists that the speech function is located in some strictly definite areas of the left hemisphere: Broca’s area in the rear part of the lower frontal gyrus (Brodmann area 44, or BA44), and Wernicke’s area in the rear part of the upper temporal gyrus (BA22). However, data collected with the contemporary neurovisual research methods, in particular, with functional magnetic resonance imaging (fMRI), disprove the localizationist theory of speech. With the specially designed speech task (paradigm) consisted of sentence reading and sentence continuation tests, we researched distribution of speech neuron network in healthy people and its reorganization in patients with different types of aphasia. After processing of control sample data, we noticed activation of classic speech areas (Broca’s and Wernicke’s) and their right hemisphere homologies. However, the amount of activations was predominant in the left hemisphere. We also noticed bilateral activity in lower parts of pre-central (BA4) and post-central (BA1) gyri, in cerebellum hemispheres and in visual cortex (BA17–18). In stroke patients activation in Broca’s and Wernicke’s areas depended on a lesion location. Activation wasn’t registered in case of damage of corresponding region, but it was migrated on perilesional area. We revealed new regions of activity at patients with aphasia, including upper parietal gyrus (BA7), angular and over-marginal gyri (BA39–40). Aforementioned activations were disclosed both in left and right hemispheres. The research shows that the speech paradigm used demonstrates functioning of speech system in the optimal way. The received data will increase understanding of brain structures involved in process of speech and their importance for recovery of damaged speech functions.

 

About the authors

A. V. Belopasova

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Author for correspondence.
Email: platonova@neurology.ru
Russian Federation

A. S. Kadykov

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Email: platonova@neurology.ru
Russian Federation

R. N. Konovalov

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Email: platonova@neurology.ru
Russian Federation

E. I. Kremneva

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Email: platonova@neurology.ru
Russian Federation

References

  1. Кадыков А.С. Адаптация к нарушениям общения. Медицинская реабилитация. Руководство под ред. В.М. Боголепова. Пермь: ПК «Звезда», 1998. Т1: 592–615.
  2. Кадыков А.С., Черникова Л.А., Шахпаронова Н.В. Реабилитация неврологических больных. М: МЕДпресс-информ, 2008.
  3. Коновалова Е.В. Нарушение высших психических функций и состояние мозгового кровотока при подкорковой локализации очагов у больных с сосудистыми заболеваниями мозга. Дис. канд. мед. наук 14.00.13. М.: 2000.
  4. Лурия А.Р. Высшие корковые функции человека. М.: 1962: 431с.
  5. Цветкова Л.С. Нейропсихологическая реабилитация больных. 2-е изд. М.: Издательство Московского психолого-социального института 2004.
  6. Шмидт Е.В., Макинский Т.А. Мозговой инсульт, социальные последствия. Журн. невропат. и психиатр. 1979; 9: 1288–1295.
  7. Bersano A., Burgio F., Gattinoni M., Candelise L., PROS II Study Group. Aphasia burden to hospitalized acute stroke patients: need for an early rehabilitation programme. Int. J. Stroke 2009; 4(6): 443–447.
  8. Berthier M.L. Posstroke aphasia: epidemiology, pathophysiology and treatment. Drugs Aging. 2005; 22(2): 163–182.
  9. Cao Y., Vikingstad E.M., George K.P. et al. Cortical language activation in stroke patients recovering from aphasia with functional MRI. Stroke 1999; 30: 2331–2340.
  10. Engstrom M., Ragnehed M., Lundberg P., Soderfeldt B. Paradigm design of sensory-motor and language tests in clinical fMRT. Clinical.Neurophysio. 2004; 34: 267–277.
  11. Fernandes B., Cardebat D., Demonet J.-F. et al. Functional MRI follow-up study of language processes in healthy subjects and during recovery in case of aphasia. Stroke 2004; 35: 2171–2176.
  12. Frost J.A., Binder J.R., Springer J.A. et al. Language processing is strongly left lateralized in both sexes. Evidence from functional MRI. Brain 1999; 122 (2): 199–208.
  13. Goodglass H., Kaplan E., Barresi B. The assessment of aphasia and related disorders. Philadelphia: Lippincott Williams & Wilkins, 2000.
  14. Henry J.D., Crawford J.R. A meta-analytic review of verbal fluency performance following focal cortical lesions. Neuropsychology 2004;
  15. (2): 284–295.15. Ojemann G.A., Ojemann J.G., Lettich E., Berger M.S. Cortical language localization in left dominant hemisphere. An electrical stimulation mapping investigation in 117 patients. J. Neurosurg. 1989; 71: 316–326.
  16. Sakai K.L., Hashimoto R., Homae F. Sentence processing in the cerebral cortex. Neurosci. Res. 2001; 39: 1–10.
  17. Sinai A., Bowers C.W., Crainiceanu C.M. et al. Electrocorticograpfic high gamma activity versus electrical cortical stimulation mapping of naming. Brain 2005; 128: 1556–1570.
  18. Szaflarski J.P., Eaton K., Ball A.L. et al. Poststroke aphasia recovery with functional magnetic resonance imaging and a picture identification task. J. Stroke Cerebrovasc. Dis. 2010; 17.
  19. Thulborn K.R., Carpenter P.A., Just M.A. Plasticity of languaderelated brain function during recovery from stroke. Stroke 1999; 30: 749–754.
  20. Toga A., Mazziotta J. Brain mapping: The Systems. San Diego, Calif: Academic Pres., 2000.
  21. Tsouli S., Kyritsis A.P., Tsagalis G. et al. Significance of aphasia after first-ever acute stroke: impact on early and late outcomes. Neuroepidemiology 2009; 33 (2): 96–102.
  22. Tzourio N., Crivello F., Mellet E. et al. Functional anatomy of dominance for speech comprehension in left handlers vs right handlers. Neuroimage 1998; 8 (1): 1–16.

Copyright (c) 2013 Belopasova A.V., Kadykov A.S., Konovalov R.N., Kremneva E.I.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77-83204 от 12.05.2022.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies