Role of modern neuroimaging in the studies of focal dystonia

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Presented is a detailed analysis of different modern neuroimaging technologies used for studying pathophysiological mechanisms and morpho-physiological substrate of primary focal dystonia. Main attention is paid to functional MRI and voxel-based morphometry. Various applications of these methods for the purposes of basic neurology and neurophysiology, as well as for control of the effects of ongoing treatment, are summarized and discussed.


About the authors

S. L. Timerbaeva

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Author for correspondence.
Russian Federation


  1. Иллариошкин С.Н., Иванова-Смоленская И.А., Маркова Е.Д. ДНК-диагностика и медико-генетическое консультирование. М.: МИА, 2003.
  2. Костич В.С. Дистонические синдромы: современное состояние проблемы. В кн.: Болезнь Паркинсона и расстройства движений. Руководство для врачей (под ред. Иллариошкина С.Н., Яхно Н.Н.). М., 2008: 213–216.
  3. Маркова Е.Д. Дистонические гиперкинезы. В кн.: Экстрапирамидные расстройства. Руководство по диагностике и лечению (под. ред. Штока В.Н., Ивановой-Смоленской И.А., Левина О.С.). М.: МЕДпресс-информ, 2002: 282–290.
  4. Baker R.S., Andersen A.H., Morecraft R.J., Smith C.D. A functional magnetic resonance imaging study in patients with benign essential blepharospasm. J. Neuroophthalmol. 2003; 23: 11–15.
  5. Black K.J., Ongur D., Perlmutter J.S. Putamen volume in idiopathic focal dystonia. Neurology. 1998; 51: 819–824.
  6. Blood A.J., Flaherty A.W., Choi J.K. et al. Basal ganglia activity remains elevated after movement in focal hand dystonia. Ann. Neurol. 2004; 55: 744–748.
  7. Blood A.J., Tuch D.S., Makris N. et al. White matter abnormalities in dystonia normalize after botulinum toxin treatment.Neuro. Report. 2006; 17: 1251–1255.
  8. Bonilha L., de Vries P.M., Vincent D.J. et al. Structural white matter abnormalities in patients with idiopathic dystonia. Mov. Disord. 2007; 22: 1110–1116.
  9. Bradley D., Whelan R., Walsh R. et al. Comparing endophenotypes in adult-onset primary torsion dystonia. Mov. Disord. 2010; 25:84–90.
  10. Breakefield X.O., Blood A.J., Li Y. et al. The pathophysiological basis of dystonias. Nat Rev. Neurosci. 2008; 9(3): 222–34.
  11. Butterworth S., Francis S., Kelly E. et al. Abnormal cortical sensory activation in dystonia: an fMRI study. Mov. Disord. 2003; 18: 673–682.
  12. Ceballos-Baumann A.O., Sheean G., Passingham R.E. et al. Botulinum toxin does not reverse the cortical dysfunction associated with writer’s cramp. A PET study. Brain. 1997;120:571–582.
  13. Colosimo C., Pantano P., Calistri V. et al. Diffusion tensor imaging in primary cervical dystonia. J. Neurol. Neurosurg. Psychiatry. 2005; 76: 1591–1593.
  14. Delmaire C., Krainik A., Tezenas du M.S. et al. Disorganized somatotopy in the putamen of patients with focal hand dystonia. Neurology. 2005; 64:1391–1396.
  15. Delmaire C., Vidailhet M., Elbaz A. et al. Structural abnormalities in the cerebellum and sensorimotor circuit in writer’s cramp. Neurology. 2007; 69: 376–380.
  16. Delmaire C., Vidailhet M., Wassermann D. et al. Diffusion abnormalities in the primary sensorimotor pathways in writer’s cramp. Arch. Neurol. 2009; 66: 502–508.
  17. de Vries P.M., Johnson K.A., de Jong B.M. et al. Changed patterns of cerebral activation related to clinically normal hand movement in cervical dystonia. Clin. Neurol. Neurosurg. 2008; 110: 120–128. 53 ТЕХНОЛОГИИ Нейровизуализация при фокальной дистонии
  18. Draganski B., Thun-Hohenstein C., Bogdahn U. et al. “Motor circuit” gray matter changes in idiopathic cervical dystonia. Neurology. 2003; 61: 1228–1231.
  19. Dresel C., Haslinger B., Castrop F. et al. Silent event-related fMRI reveals deficient motor and enhanced somatosensory activation in orofacial dystonia. Brain. 2006; 129: 36–46
  20. Dresel C., Bayer F., Castro F. et al. Botulinum Toxin Modulates Basal Ganglia But Not Deficient Somatosensory Activation in Orofacial Dystonia. Mov. Disord. 2011; 26: 1496–1502.
  21. Egger K., Mueller J., Schocke M. et al. Voxel based morphometry reveals specific gray matter changes in primary dystonia. Mov. Disord. 2007; 22:1538–1542.
  22. Epidemiological Study of Dystonia in Europe (ESDE) Collaborative Group. J. Neurol. 2000; 247: 787–792.
  23. Esmaeli-Gutstein B., Nahmias C., Thompson M. et al. Positron emission tomography in patients with benign essential blepharospasm. Ophthalmic. Plast. Reconstr. Surg. 1999; 15: 23–27.
  24. Etgen T., Muhlau M., Gaser C., Sander D. Bilateral grey-matter increase in the putamen in primary blepharospasm. J. Neurol. Neurosurg. Psychiatry. 2006; 77: 1017–1020.
  25. Fabbrini G., Pantano P., Totaro P. et al. Diffusion tensor imaging in patients with primary cervical dystonia and in patients with blepharospasm. Eur. J. Neurol. 2008; 15: 185–189.
  26. Feiwell R.J., Black K.J., McGee-Minnich L.A. et al. Diminished regional cerebral blood flow response to vibration in patients with blepharospasm. Neurology. 1999; 52: 291–297.
  27. Garraux G., Bauer A., Hanakawa T. et al. Changes in brain anatomy in focal hand dystonia. Ann. Neurol. 2004; 55: 736–739.
  28. Granert O., Peller M., Gaser C. et al. Manual activity shapes structure and function in contralateral human motor hand area. Neuroimage. 2011; 54: 32–41.
  29. Granert O., Peller M., Jabusch H.C. et al. Sensorimotor skills and focal dystonia are linked to putaminal grey-matter volume in pianists. J.N.N.P. 2011; 24: 1–7.
  30. Haslinger B., Erhard P., Dresel C. et al. “Silent event-related” fMRI reveals reduced sensorimotor activation in laryngeal dystonia. Neurology. 2005; 65: 1562–1569.
  31. Hu X.Y., Wang L., Liu H., Zhang S.Z. Functional magnetic resonance imaging study of writer’s cramp. Chin. Med. J. 2006; 119: 1263–1271.
  32. Huang S.C., Carson R.E., Hoffman E.J. et al. Quantitative measurement of local cerebral blood flow in humans by positron computed tomography and 15O-water.J. Cereb. Blood Flow Metab. 1983; 3: 141–153.
  33. Hutchinson M., Nakamura T., Moeller J.R. et al. The metabolic topography of essential blepharospasm: a focal dystonia with general implications. Neurology. 2000; 55: 673–677.
  34. Ibanez V., Sadato N., Karp B. et al. Deficient activation of the motor cortical network in patients with writer’s cramp. Neurology. 1999; 53: 96–105.
  35. Islam T., Kupsch A., Bruhn H. et al. Decreased bilateral cortical representation patterns in writer’s cramp: a functional magnetic resonance imaging study at 3.0 T. Neurol. Sci. 2009; 30: 219–226.
  36. Kadota H., NakajimaY., Miyazaki M. et al. An fMRI study of musicians with focal dystonia during tapping tasks. J. Neurol. 2010; 257: 1092–8.
  37. Kerrison J.B., Lancaster J.L., Zamarripa F.E. et al. Positron emission tomography scanning in essential blepharospasm. Am. J. Ophthalmol. 2003; 136: 846–852.
  38. Leenders K., Hartvig P., Forsgren L. et al. Striatal [11C]-N-methylspiperone binding in patients with focal dystonia (torticollis) using positron emission tomography. J. Neural. Transm. Park. Dis. Dement. 1993; 5: 79–87.
  39. Lerner A., Shill H., Hanakawa T. et al. Regional cerebral blood flow correlates of the severity of writer’s cramp symptoms. Neuroimage. 2004; 21: 904–913.
  40. Magyar-Lehmann S., Antonini A., Roelcke U. et al. Cerebral glucose metabolism in patients with spasmodic torticollis. Mov. Disord. 1997; 12: 704–708.
  41. Martino D., Di Giorgio A., D’Ambrosio E. et al. Cortical gray matter changes in primary blepharospasm: A voxel-based morphometry study. Mov.Disord. 2011; 26: 1907–1912.
  42. Mori S., Zhang J. Principles of diffusion tensor imaging and its applications to basic neuroscience research. Neuron. 2006; 51: 527–539.
  43. Nahab F.B., Hallett M. Current Role of Functional MRI in the Diagnosis of Movement Disorders. Neuroimag. Clin. N. Am. 2010; 20: 103–110.
  44. Naumann M., Magyar-Lehmann S., Reiners K. et al. Sensory tricks in cervical dystonia: perceptual dysbalance of parietal cortex modulates frontal motor programming. Ann. Neurol. 2000; 47: 322–328.
  45. Nelson A.J., Blake D.T., Chen R. Digit-specific aberrations in the primary somatosensory cortex in Writer’s cramp. Ann Neurol. 2009; 66: 146-154.
  46. Obermann M., Yaldizli O., De G.A. et al. Morphometric changes of sensorimotor structures in focal dystonia. Mov. Disord. 2007; 22:1117–1123.
  47. Odergren T., Stone-Elander S., Ingvar M. Cerebral and cerebellar activation in correlation to the action-induced dystonia in writer’s cramp. Mov. Disord. 1998; 13: 497–508.
  48. Oga T., Honda M., Toma K. et al. Abnormal cortical mechanisms of voluntary muscle relaxation in patients with writer’s cramp: an fMRI study. Brain. 2002; 125: 895–903.
  49. Ogawa S., Lee T., Nayak A. et al. Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn. Reson. Med. 1990; 14: 68–78.
  50. Opavsky R., Hlustik P., Otruba P., Kanovsky P. Sensorimotor network in cervical dystonia and the effect of botulinum toxin treatment: A functional MRI study. J. Neurol. Sci. 2011; 306: 71–75.
  51. Pantano P., Totaro P., Fabbrini G. et al. A transverse and longitudinal MR imaging voxel-based morphometry study in patients with primary cervical dystonia. Am. J. Neuroradiol. 2011; 32: 81–84.
  52. Peller M., Zeuner K.E., Munchau A. et al. The basal ganglia are hyperactive during the discrimination of tactile stimuli in writer’s cramp. Brain. 2006; 129: 2697–2708.
  53. Perlmutter J.S., Stambuk M.K., Markham J. et al. Decreased [18F]spiperone binding in putamen in idiopathic focal dystonia. J. Neurosci. 1997; 17: 843–850. 54. Preibisch C., Berg D., Hofmann E. et al. Cerebral activation patterns in patients with writer’s cramp: a functional magnetic resonance imaging study. J.Neurol. 2001; 248: 10–17.
  54. Pujol J., Roset-Llobet J., Rosines-Cubells D. et al. Brain cortical activation during guitarinduced hand dystonia studied by functional MRI. Neuroimage. 2000; 12: 257–267.
  55. Reivich M., Kuhl D., Wolf A. et al. A model of diaschisis in the cat using middle cerebral artery occlusion. Acta Neurol. Scand. 1977; Suppl; 64:190.
  56. Roy C., Sherrington C. On the regulation of the blood supply of the brain. J. Physiol. 1890; 11: 85–108.
  57. Schmidt K.E., Linden D.E., Goebel R. et al. Striatal activation during blepharospasm revealed by fMRI. Neurology. 2003; 60: 1738–1743.
  58. Simonyan K., Ludlow C.L. Abnormal activation of the primary somatosensory cortex in spasmodic dysphonia: an fMRI study. Cereb. Cortex. 2010; 20: 2749–2759.
  59. Suzuki Y., Mizoguchi S., Kiyosawa M. et al. Glucose hypermetabolism in the thalamus of patients with essential blepharospasm. J. Neurol. 2007; 254: 890–896.
  60. Ter-Pogossian M.M., Phelps M.E., Hoffman E.J. et al. A positronemission transaxial tomograph for nuclear imaging (PETT). RadiologyRadiology. 1975; 114: 89–98.
  61. Wu C.C., Fairhall S.L., McNair N.A. et al. Impaired sensorimotor integration in focal hand dystonia patients in the absence of symptoms. J. Neurol. Neurosurg. Psychiatry. 2010; 81: 659–665.
  62. Zoons E., Booij J., Nederveen A.J. et al. Structural, functional and molecular imaging of the brain in primary focal dystonia – A review. NeuroImage. – 2011; 56: 1011–1020.

Copyright (c) 2012 Timerbaeva S.L.

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