Principles of diffusion tensor imaging and its application to neuroscience

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This review article deals with technical issues of diffusion weighted imaging (DWI), diffusion tensor imaging (DTI) and magnetic resonance tractography. We define such parameters of DWI like: apparent diffusion coefficient, b-factor, fractional anisotropy (FA) and diffusion tensor. We retell about main algorithms of MR-tractography pointing their specifics and drawbacks. We explore aspects of DTI in clinical neuroradiology and neuroscience for diagnosis and evaluation of axonal injury, demyelinization, tumors, peripheral nerves injuries, spinal cord diseases and brain development in late embryonic and neonatal period. We explain, how DTI allows to judge about micro-architecture of a brain going into details on technical issues, limiting an application of DTI only on small animals ex vivo.


About the authors

S. V. Kitaev

Research Center of Neurology, Russian Academy of Medical Sciences

Russian Federation, Moscow

T. A. Popova

Research Center of Neurology, Russian Academy of Medical Sciences

Author for correspondence.
Russian Federation, Moscow


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Copyright (c) 2012 Kitaev S.V., Popova T.A.

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