Regulatory T-cells CD4+CD25+Foxр3+ in patients with remitting multiple sclerosis

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Abstract

In the maintenance of immunological tolerance a recently discovered population of regulatory T-cells CD4+CD25+Foxp3+ (Treg) plays an important role. These cells have potential in suppressing pathologic immune response observed in various autoimmune diseases, including multiple sclerosis. In the present work, we showed reduction in the number and functional activity of Treg in peripheral blood of patients with multiple sclerosis in the acute stage, as well as increase in Treg content in the disease remission and relation of the Treg content with duration of the autoimmune process and the degree of disability of patients.

 
 

About the authors

D. D. Eliseeva

Research Center of Neurology, Russian Academy of Medical Sciences

Email: delis.82@mail.ru
Russian Federation, Moscow

I. A. Zavalishin

Research Center of Neurology, Russian Academy of Medical Sciences

Email: delis.82@mail.ru
Russian Federation, Moscow

S. N. Bykovskaya

Russian State Medical University named after N.I. Pirogov

Email: delis.82@mail.ru
Russian Federation, Moscow

T. N. Fedorova

Research Center of Neurology, Russian Academy of Medical Sciences

Email: delis.82@mail.ru
Russian Federation, Moscow

E. N. Karandashov

Russian State Medical University named after N.I. Pirogov

Email: delis.82@mail.ru
Russian Federation, Moscow

O. A. Trunova

Research Center of Neurology, Russian Academy of Medical Sciences

Author for correspondence.
Email: delis.82@mail.ru
Russian Federation, Moscow

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Copyright (c) 2011 Eliseeva D.D., Zavalishin I.A., Bykovskaya S.N., Fedorova T.N., Karandashov E.N., Trunova O.A.

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