Cerebral radio-necrosis in a patient with pseudo-tumoral multiple sclerosis

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Abstract

A pseudo-tumoral course of multiple sclerosis is very rare. In the paper, a morphologically confirmed case of multiple sclerosis with a pseudo-tumoral course is described. A radiation treatment (because of a misdiagnosis of cerebral tumor) resulted in radio-necrosis of the cerebral tissue. Presented are the experience of treatment of this patient, differential diagnosis and efficacy of the long-term hormone therapy.

 

About the authors

O. E. Guryanova

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Author for correspondence.
Email: platonova@neurology.ru
Russian Federation

N. I. Stoyda

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Email: platonova@neurology.ru
Russian Federation

R. N. Konovalov

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Email: platonova@neurology.ru
Russian Federation

I. A. Zavalishin

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Email: platonova@neurology.ru
Russian Federation

References

  1. Бембеева Р.Ц., Серков С.В., Пронин И.Н., Коршунов А.Г. Случай острого воспалительного демиелинизирующего процесса с псевдотуморозным течением. Журн. неврол. и психиатрии им. С.С. Корсакова 2007; 1: 63–67.
  2. Гусев Е.И., Бойко А.Н., Силуянова В.А. и др. Варианты течения и прогноз при рассеянном склерозе. В кн.: Гусев Е.И.. Завалишин И.А., Бойко А.Н. (ред.). Рассеянный склероз и другие демиелинизирующие заболевания. М.: Миклош, 2004: 158–180.
  3. Завалишин И.А., Гулевская Т.С., Моргунов В.А. и др. Псевдотуморозное течение рассеянного склероза (клинико-морфологическое исследование). Журн. неврол. и психиатрии им. С.С. Корсакова, прилож. «Рассеянный склероз» 2007; 4: 79–83.
  4. Михалина З.П., Ткачев С.И., Трофимова О.П. и др. Лучевая терапия в комбинированном и комплексном лечении метастазов в головной мозг: основные этапы, перспективы. В сб.: X Российский Онкологический Конгресс. ГУ РОНЦ им. Н.Н. Блохина РАМН, 2008.
  5. Annesley-Williams D., Farrell M. A., Staunton H., Brett F.M. Acute demyelination, neuropathological diagnosis, and clinical evolution. J. Neuropathol Exp. Neurol. 2000; 59: 477–489.
  6. Brandes A.A., Tosoni A., Spagnolli F. et al. Disease progression or pseudoprogression after concomitant radiochemotherapy treatment: Pitfalls in neurooncology. Neuro-oncology 2008; 15: 361–367.
  7. Ciaudo-Lacroix C., Lapresle J. Pseudo-tumoral form of delayed radionecrosis of the brain. Ann. Med. Interne 1985; 136: 137–141.
  8. Fujii T., Misumi S., Shibasaki T. et al. Treatment of delayed brain injury after pituitary irradiation. No Shinkei Geka 1988; 16: 241–247.
  9. Kumar A.J., Leeds N.E., Fuller G.N. et al. Malignant gliomas: MR imaging spectrum of radiation therapy- and chemotherapy-induced necrosis of the brain after treatment. Radiology Nov. 2000; 217: 377–384.
  10. Lucchinetti C.F., Gavrilova R.H., Metz I. et al. Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis. Brain 2008; 131: 1759–1775.
  11. Poser S., Luer W., Bruhn J. et al. Acute demyelinating disease. Classification and non-invasive diagnosis. Acta Neurol. Scand. 1992; 86: 579–585.
  12. Seewann A., Enzinger C., Barkhof F. et al. MRI characteristics of atypical idiopathic inflammatory demyelinating lesions of the brain. J. Neurol. 2008; 255: 1–10.
  13. Sugita Y., Terasaki M., Shigemori M. et al. Acute focal demyelinating disease simulating brain tumors: histopathologic diagnosis for an accurate diagnosis. Neuropathology 2001; 21: 25–31.
  14. Zagzag D., Miller D.C., Kleinman G.M. et al. Demyelinating disease versus tumor in surgical neuropathology: clues to a correct pathological diagnosis. Am. J. Surg. Pathol. 1993; 17: 537–545.
  15. Zrando L.A., Domingues R.C. MR spectroscopy of the brain. Philadelphia: Lippincott Williams&Wilkins, 2004.

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Copyright (c) 2017 Guryanova O.E., Stoyda N.I., Konovalov R.N., Zavalishin I.A.

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