Functional characteristics of the brain and cognitive functions in patients with autonomic dysfunction combined with clinically apparent asthenia

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Twenty six patients with autonomic dysfunction combined with clinically apparent asthenia and 22 healthy control subjects were examined with the use of clinico-neurologic, psychometric, neuropsychological and neurophysiological methods of investigation. Electrophysiologically, compression spectral analysis of EEG and auditory event-related potentials Р300 were used. The patients differed significantly from controls by the reduced attention selectivity, stability and switching, as well as by depression of short-term memory on words and digits. The patients group was also characterized by significantly lower Р300 wave amplitude and spectral power of EEG alpha band in the occipital areas of both hemispheres, in the posterior frontal, the central and the parietal areas of the right hemisphere, as well as by significantly higher spectral power of EEG theta band in the right frontal, the left parietal and the central areas of both hemispheres. One may conclude hat changes of spontaneous and evoked electrical activity of the brain in patients with an asthenia reflect the decrease in general level of brain functional activity owing to abnormal adjusting influences of the limbic-reticular structures. In this case a sufficient flow of cortical activation, necessary for the optimal information processing and maintenance of an adequate level of the directed attention and short-term memory, can not be generated.


About the authors

S. A. Gordeev

Research Center of Neurology, Russian Academy of Medical Sciences

Russian Federation, Moscow

S. B. Shvarkov

1st Moscow State Medical University named after I.M. Sechenov

Russian Federation, Moscow

G. V. Kovrov

1st Moscow State Medical University named after I.M. Sechenov

Russian Federation, Moscow

S. I. Posokhov

1st Moscow State Medical University named after I.M. Sechenov

Russian Federation, Moscow

N. A. Dyakonova

Psychoneurological dispensary № 14

Author for correspondence.
Russian Federation, Moscow


  1. Боголепов Н.Н., Фокин В.Ф. Функциональная межполушарная асимметрия. Хрестоматия. М.: Научный мир, 2004.
  2. Вейн А.М., Дюкова Г.М., Воробьева О.В., Данилов А.Б. Панические атаки. М.: Эйдос Медиа, 2004.
  3. Гордеев С.А. Применение метода эндогенных связанных с событиями потенциалов мозга Р300 для исследования когнитивных функций в норме и клинической практике. Физиология человека 2007; 33: 121–133.
  4. Гордеев С.А. Психофизиологическое исследование внимания при астено-невротических расстройствах. Межд. неврол. журн. 2007; 1: 78–82.
  5. Горев А.С. Динамика ритмических составляющих ЭЭГ в условиях релаксации у школьников 9–10 лет с различной успешностью обучения. Физиология человека 1998; 24: 42–47.
  6. Ильюченок И.Р. Различия частотных характеристик ЭЭГ при восприятии положительно-эмоциональных, отрицательно-эмоциональных и нейтральных слов. Журн. высш. нерв. деят. 1996; 46: 457–468.
  7. Крейндлер А. Астенический невроз. Бухарест, 1963.
  8. Наатенен Р. Внимание и функции мозга. М.: Изд–во МГУ, 1998.
  9. Хомская Е.Д. Мозг и активация. М.: Изд-во МГУ, 1972.
  10. Hanaoka A., Kikuchi M., Komuro R. et al. EEG coherence analysis in never-medicated patients with panic disorder. Clin. EEG Neurosci. 2005; 36: 42–48.
  11. Hanatani T., Sumi N., Taguchi S. et al. Event-related potentials in panic disorder and generalized anxiety disorder. Psychiatry Clin. Neurosci. 2005; 59: 83–88.
  12. Ivan A.B., Polich J. P300 and response time from a manual Stroop task. Clin. Neurophysiol. 1999; 110: 367–373.
  13. Kropotov J.D., Ponomarev V.A. Subcortical neuronal correlates of component P300 in man. EEG Clin. Neurophysiol. 1991; 78: 40–49.
  14. Lissak K., Grastyan E., Molnar L. et al. Significance of the hypothalamus and hippocampus in the higher nervous activity. Cesk. Fysiol. 1957; 6: 461–466.
  15. Newton T.F., Leuchter A.F., Van Gorp W.G. et al. EEG power correlates with subcortical metabolic activity in AIDS. J. Neuropsychiatry Clin. Neurosci. 1997; 9: 574–578.
  16. Pauli P., Amrhein C., Muhlberger A. et al. Electrocortical evidence for an early abnormal processing of panic-related words in panic disorder patients. Int. J. Psychophysiol. 2005; 57: 33–41.
  17. Polich J., Kok A. Cognitive and biological determinants of P300: an integrative review. Biol. Psychol. 1995; 41: 103–146.
  18. Polich J., Squire L.R. P300 from amnesic patients with bilateral hippocampal lesion. EEG Clin. Neurophysiol. 1993; 86: 408–417.

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Copyright (c) 2010 Gordeev S.A., Shvarkov S.B., Kovrov G.V., Posokhov S.I., Dyakonova N.A.

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