Sleep disturbances in patients with chronic brain ischemia and metabolic syndrome

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Abstract

Complains of patients with chronic brain ischemia (CBI) and metabolic syndrome (MS) on disturbed sleep do not reflect an objective picture of sleep problems, from the viewpoint of both respiratory abnormalities during sleep and changes in the sleep structure. Sleep disturbances may result from two principally different pathogenic processes: secondary sleep abnormalities due to apnea and psychophysiological insomnia on the background of severe psycho-vegetative syndrome with anxiety and depression. Polysomnographic examination should be a component of a complex of essential para-clinical investigations in patients with CBI and MS, since only this method may allow determining with certainty pathogenic character of sleep disturbances and establishing pharmaco-therapeutic strategy.

 

About the authors

O. V. Lyubshina

Moscow State Medical-Stomatologic University

Author for correspondence.
Email: platonova@neurology.ru
Russian Federation

M. Yu. Maximоva

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Email: platonova@neurology.ru
Russian Federation

References

  1. Вейн А.М. Нарушения сна и бодрствования. М.: Медицина, 1974: 384.
  2. Вейн А.М., Хехт К. Сон человека. Физиология и патология. М.: Медицина, 1989: 272.
  3. Вейн А.М., Елигулашвили Т.С., Полуэктов М.Г. Синдром апноэ во сне и другие расстройства дыхания, связанные со сном: кли- ника, диагностика, лечение. СПб.: Эйдос медиа, 2002: 310.
  4. Бабак С.Л., Голубев П.А., Григорьянц Р.А. Расстройства дыхания во время сна / Под ред. А.Г. Чучалина. М., 1999: 136.
  5. Бутрова С.А. Метаболический синдром: патогенез, клиническая диагностика, подходы к лечению. Рус. мед. журн. 2004; 1: 3–9.
  6. Инсомния, современные диагностические и лечебные подходы / Под ред. Я.И. Левина. М.: Медпрактика, 2005.
  7. Левин Я.И. Клиническая сомнология: проблемы и решения. Неврол. журн. 2004; 9 (4): 4–13.
  8. American Academy of Sleep Medicine Task Force. Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. Sleep 1999; 22: 667–789.
  9. American Medical Association. Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486–2497.
  10. Gami A.S., Howard D.E., Olson E.J., Somers V.K. Day-night pattern of sudden death in obstructive sleep apnea. N. Engl. J. Med. 2005; 352: 1206–1214.
  11. Gruber A., Horwood F., Sithole J. et al. Obstructive sleep apnoea is independently associated with metabolic syndrome but not the insulin resistance state. Cardiovasc. Diabetol. 2006; 5: 22.
  12. Lam J.C.M., Lam B., Lam C.L. et al. Obstructive sleep apnea and the metabolic syndrome in community-based Chinese subjects in Hong Kong. Respir. Med. 2006; 100: 980–987.
  13. Leineweber C., Kecklung G., Akerstedt T. et al. Sleep Med. 2003; 4 (6): 531–536.
  14. Mendelson W. Impact of insomnia: wide-reaching burden and a conceptual framework for comorbidity. Int. J. Sleep Wakefulness 2008; 1: 118–123.
  15. Newman A.B., Nieto F.J., Guidry U. et al. Relationship of sleep-disordered breathing to cardiovascular risk factors. The Sleep Heart Health Study. Am. J. Epidemiol. 2001; 154: 50–59.
  16. Perlis M.L., Smith M.T., Pigeon W.R. Etiology and pathophysiology of insomnia. In: Kryger M.H., Roth T., Dement W.C., eds. Principles and practice of sleep medicine. 4th ed. Philadelphia: Elsevier/Saunders, 2005: 714–25.
  17. Phillips B., Mannino D.M. Does insomnia kill? Sleep 2005; 28: 965–971.
  18. Reaven G. Metabolic syndrome: pathophysiology and implications for management of cardiovascular disease. Circulation 2002; 106: 286–288.
  19. Redline S., Storfer-Isser A., Rosen C.L. et al. Association between metabolic syndrome and sleep disordered breathing in adolescents. Am. J. Respir. Crit. Care Med. 2007; 31.
  20. Roux F., D’Ambrosio C., Mohsenin V. Sleep-related breathing disorders and cardiovascular disease. Am. J. Med. 2000; 108: 396–402.
  21. Scheen A.J. Clinical study of the month. Does chronic sleep deprivation predispose to metabolic syndrome. Rev. Med. Liege 1999; 54: 898–900.
  22. Shahar E., Whitney C.W., Redline S. et al. Sleep-desordered breathing and cardiovascular disease – cross sectional results of the Sleep Heart Health Study. Am. J. Respir. Crit. Care Med. 2001; 163: 19–25. 23. Wilcox I., McNamara S.G., Collins F.L. et al. «Syndrome Z»: the interaction of sleep apnoea, vascular risc factors and heart disease. Thorax 1998; 53: 25–28.
  23. Young T., Peppard P.E., Gottieb D.J. et al. Epidemiology of obstructive sleep apnea. Am. J. Respir. Crit. Care Med. 2002; 165: 1217–1239.

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Copyright (c) 2017 Lyubshina O.V., Maximоva M.Y.

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