Cerebral hemodynamics in vertebrobasilar pathology, as for the issue of vertebrobasilar insufficiency

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A study of the functional state of cerebral hemodynamics (blood flow velocity and hemodynamic reserve in the basilar artery) using transcranial Doppler with nitroglycerine test has been carried out in 18 patients with ischemic stroke in vertebrobasilar circulation and 20 patients with and/or symptoms suggestive of posterior circulation disease. Significant decrease of the parameters of cerebral hemodynamic reserve was shown in patients with a history of ischemic stroke and also in patients with atherosclerotic obstructive lesions of the vertebral arteries. On the other hand in patients with the anomalies of the vertebral arteries (kinking, hypoplasia) blood flow in vertebrobasilar circulation was normal. Therefore these patients need not of the surgical preventive treatment


About the authors

D. Yu. Barkhatov

Research Center of Neurology, Russian Academy of Medical Sciences

Author for correspondence.
Email: platonova@neurology.ru
Russian Federation, Moscow


  1. Barrett K., Ackerman R., Gahn G. et al. Basilar and middle cerebral artery reserve. A comparative study using transcranial Doppler and breath-holding techniques. Stroke 2001; 32: 2793–6.
  2. Chimovitz M., Furlan A., Jones S. et al. Transcranial Doppler assessment of cerebral perfusion reserve in patients with carotid occlusive disease and no evidence of cerebral infarction. Neurology 1993; 43: 353–7.
  3. Deredeyn C., Grubb R., Powers W. Cerebral hemodynamic impairment: methods of measurements and association with stroke risk. Neurology 1999; 53: 251–9.
  4. Garbin L., Habetswallner F., Clivati A. Vascular reactivity in middle cerebral artery and basilar artery by transcranial Doppler in normal subjects during hypoxia. Ital. J. Neurol. Sci. 1997; 18: 135–7.
  5. Savitz S., Caplan L. Vertebrobasilar disease. New. Engl. J. Med. 2005; 352: 2618–26.
  6. Silvestrini M., Vernieri F., Pasqualetti P. et al. Impaired cerebral vasoreactivity and risk of stroke in patients with asymptomatic carotid artery stenosis. JAMA 2000; 283 (16): 2122–2127.
  7. Vernieri F., Pasqualetti P., Matteis M. et al. Effect of collateral blood flow and cerebral vasomotor reactivity on the outcome of carotid artery occlusion. Stroke 2001; 32: 1552–8.
  8. Wan Park C., Sturzenegger M., Douville C. et al. Autoregulatory Response and CO2 Reactivity of the Basilar Artery. Stroke 2003; 34: 34–39.
  9. Webster M., Makaroun M., Steed D. et al. Compromised cerebral blood flow reactivity is a predictor of stroke in patients with symptomatic carotid artery occlusive disease. J. Vasc. Surg. 1995; 21.

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Copyright (c) 2009 Barkhatov D.Y.

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