Rasmussen’s encephalitis with adult onset

Cover Page

Abstract

Rasmussen’s encephalitis (RE) is a rare inflammatory brain disease characterized by severe intractable epilepsy and unilateral progressive motor defect associated with contralateral hemispheric atrophy. The authors present clinical features, EEG and MRI data and results of effective treatment of patient with adult onset RE. Despite the predominance of RE in children, stressed is the necessity of taking into consideration this condition in adults as well in differential diagnostics of intractable epilepsies.

 

About the authors

A. S. Kotov

Moscow Regional Research Clinical Institute, Moscow

Author for correspondence.
Email: platonova@neurology.ru
Russian Federation

I. G. Rudakova

Moscow Regional Research Clinical Institute, Moscow

Email: platonova@neurology.ru
Russian Federation

S. V. Kotov

Moscow Regional Research Clinical Institute, Moscow

Email: platonova@neurology.ru
Russian Federation

Yu. A. Belova

Moscow Regional Research Clinical Institute, Moscow

Email: platonova@neurology.ru
Russian Federation

References

  1. Зенков Л.Р. Клиническая эпилептология (с элементами нейрофизиологии). М.: МИА, 2002.
  2. Мухин К.Ю., Глухова Л.Ю. Синдром Расмуссена (хронический прогрессирующий очаговый энцефалит, энцефалит Расмуссена) и эпилепсия Кожевникова. В кн.: Мухин К.Ю., Петрухин А.С., Глухова Л.Ю. (ред.) Эпилепсия. Атлас электро-клинической диагностики. М.: Альварес Паблишинг, 2004: 416–425.
  3. Петрухин А.С., Гуляева С.Е., Мухин К.Ю. Эпилепсия Кожевниикова и энцефалит Расмуссена. В кн.: Петрухин А.С., Мухин К.Ю., Благосклонова Н.К., Алиханов А.А. (ред.) Эпилептология детского возраста. Руководство для врачей. М.: Медицина, 2000: 117–131.
  4. BahiiBuisson N., Nabbout R., Plouin P. et al. Avancees actuelles surles concepts pathogeniques et therapeutiques de l’encephalite de Rasmussen. Rev. Neurol. (Paris) 2005; 161: 395–405.
  5. BahiiBuisson N., Villanueva V., Bulteau C. et al. Long-term response to steroid therapy in Rasmussen encephalitis. Seizure 2007; 16: 485–492.
  6. Granata T. Rasmussen’s syndrome. Neurol. Sci. 2003; 24: 239–243.
  7. Gray F., Serdaru M., Baron H. et al. Chronic localized encephalitis (Rasmussen’s) in an adult with epilepsia partialis continua. J. Neurol. Neurosurg. Psychiatry 1987; 50: 747–751.
  8. Hart Y.M., Cortez M., Andermann F. et al. Medical treatment of Rassmussen’s syndrome (chronic encephalitis and epilepsy): effect of high-dose steroids or immunoglobulins in 19 patients. Neurology 1994; 44: 1030–1036.
  9. Jaillon-Riviere V., Dupont S., Bertran F. et al. Late onset Rasmussen’s syndrome: clinical and therapeutic characteristics. Rev. Neurol. (Paris) 2007; 163: 573–580.
  10. Mantegazza R., Bernasconi P., Baggi F. et al. Antibodies against GluR3 peptides are not specific for Rasmussen’s encephalitis but are also present in epilepsy patients with severe, early onset disease and
  11. intractable seizures. J. Neuroimmunol. 2002; 131: 179–185.
  12. Rasmussen T., Obszewski J., Lloyd-Smith D. Focal seizures due to chronic localized encephalitis. Neurology 1958; 8: 435–445.
  13. Rogers S.W., Andrews P.I., Gahring L.C. et al. Autoantibodies to glutamate receptor GluR3 in Rasmussen’s encephalitis. Science 1994; 265: 648–651.
  14. Takahashi Y., Mori H., Mishina M. et al. Autoantibodies and cell-mediated autoimmunity to NMDA-type GluR epsilon-2 in patients with Rasmussen’s encephalitis and chronic progressive epilepsia partialis continua. Epilepsia 2005; 46: 152–158.
  15. Van Oetzen J., Urbah H., Junbluth S. et al. Standard magnetic resonance imaging is inadequate for patients with refractory focal epilepsy. J. Neurol. Neurosurg. Psychiatry 2002; 73: 643–674.
  16. Villani F., Pincherle A., Antozzi C. et al. Adult onset Rasmussen’s encephalitis: anatomical electrographic clinical features of 7 Italian cases. Epilepsia 2006; 47: 41–46.
  17. Villani F., Spreafico R., Farina L. et al. Positive response to immunomodulatory therapy in an adult patient with Rasmussen’s encephalitis. Neurology 2001; 56: 248–250.
  18. Wiendl H., Bien C.G., Bernasconi P. et al. GluR3 antibodies: prevalence in focal epilepsy but no specificity for Rasmussen’s encephalitis.Neurology 2001; 57: 1511–1514.

Statistics

Views

Abstract: 961

PDF (Russian): 595

Article Metrics

Metrics Loading ...

Dimensions

PlumX


Copyright (c) 2017 Kotov A.S., Rudakova I.G., Kotov S.V., Belova Y.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies