Ultrastructure of synapses of human cerebral cortex in the old age

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In the present electron-microscopic study, changes of ultrastructure of synapses in the sensory-motor and frontal cerebral cortex in humans of old age are demonstrated. Abnormalities of distribution of synaptic vesicles in the presynaptic ending and changes of  mechanisms  of  their  rapprochement  and  attachment  to  the presynaptic membrane were found. Analysis of the obtained results suggests that disturbed interaction between synaptic vesicles and presynaptic membrane represents a stage preceding the destruction and disappearance of the synapse


About the authors

N. N. Bogolepov

Research Center of Neurology, Russian Academy of Medical Sciences

Author for correspondence.
Email: platonova@neurology.ru
Russian Federation, Moscow


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Copyright (c) 2008 Bogolepov N.N.

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