Morphological changes of the choroids plexus and ventricular walls of the cerebrum following experimental intraventricular haemorrhage

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We assessed the morphological changes induced by intraventricular haemorrhage (IVH) and investigated the effects of intraventricular fibrinolytic treatment following IVH. The experiment was performed in 30 Wistar rats. In first (control) group (15 rats) animals received intraventricular injection of 40 microl autologous blood with 10 microl normal saline. In second group (15 rats) 40 microl autologous blood with 10 microl t-PA recombinant tissue plasminogen activator (t-PA) was injected in ventricular of the animals. Morphological examination of the brains were carried out 2 days and 21 days following IVH. Marked losses of the ependymal covering of the ventricular walls, choroids plexus were founded in bouth groups. The results indicate that intraventricular administered t-PA significantly enhanced the lysis of intraventricular blood clots, but r-PA (in second group) promoted delayed periventricular white matter edema formation (more 21 days).


About the authors

A. V. Shirshov

Research Center of Neurology

Russian Federation, Moscow

Tatyana S. Gulevskaya

Research Center of Neurology

ORCID iD: 0000-0003-2970-8136

D. Sci. (Med.), Prof., chief researcher, Laboratory of neuromorphology

Russian Federation, 125367, Moscow, Volokolamskoye shosse, 80

V. A. Morgunov

Research Center of Neurology

Russian Federation, Moscow

V. G. Kucheryanu

Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences

Author for correspondence.
Russian Federation, Moscow


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Copyright (c) 2008 Shirshov A.V., Gulevskaya T.S., Morgunov V.A., Kucheryanu V.G.

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