Pathogenic heterogenety of ischemic stroke and patent foramen ovale

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The comparative analysis of pathogenic mechanisms of ischemic stroke in patients with and without Patent Foramen Ovale (PFO) was performed. 101 patients with cryptogenic stroke and stroke of known etiology were examined. All patients underwent a diagnostic protocol including brain CT/MRI scan, haemostatic system testing, ECG, standard echocardiography, transthoracal echocardiography with bubble test and transcranial Doppler with bubble test; 51 patient underwent transesophageal echocardiography. PFO was found in half of the patients with ischemic stroke. However, the paradoxical cerebral embolism could not be considered as a main stroke risk factor in the studied cases: the mechanism of stroke in PFO was clarified with the same frequency, as in patients without PFO. So, in the presence of other competing risk factors of cerebral lesion, PFO does not play independent pathogenic role in the genesis of brain ischemia.


About the authors

Z. A. Suslina

Research Centre of Neurology

Russian Federation, Moscow

Andrey V. Fonyakin

Research Center of Neurology

ORCID iD: 0000-0001-5452-2152

D. Sci. (Med.), Prof., leading researcher, Head, Laboratory of cardioneurology, 2nd Neurological department, Institute of Clinical and Preventive Neurology

Russian Federation, Moscow

Andrey O. Chechetkin

Research Center of Neurology

Author for correspondence.
ORCID iD: 0000-0002-8726-8928

D. Sci. (Med.), Head, Ultrasound diagnostic laboratory

Russian Federation, Moscow

M. V. Glebov

Research Center of Neurology, Russian Academy of Medical Sciences

Russian Federation, Moscow

Lyudmila A. Geraskina

Research Center of Neurology

ORCID iD: 0000-0002-1253-1082
Russian Federation, Moscow, Volokolamskoe shosse,80

Yu. M. Nikitin

Research center of Neurology

Russian Federation, Moscow

Mikhail A. Kravchenko

Research Center of Neurology

Russian Federation, Moscow


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Copyright (c) 2008 Suslina Z.A., Fonyakin A.V., Chechetkin A.O., Glebov M.V., Geraskina L.A., Nikitin Y.M., Kravchenko M.A.

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