Genetics of migraine

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Abstract

Hereditary factor increases the risk of migraine and underlies in many respects the development of symptoms and the disease course. Last years, basic genetic studies in migraine resulted in impressive achievements, which gave the key to understanding pathophysiological processes in this disease. At the same time, many questions remain unanswered. Most interesting is the search for genetic markers of migraine and their phenotypical correlates. From practical viewpoint, equally promising in migraine heredity studies are pharmacogenetic aspects, namely, identification of genetic predictors of the efficacy of particular medications. In this review, modern approaches to genetic studies in migraine are discussed, and presently known genetic biomarkers and their possible role in the disease development are presented.

 

About the authors

J. E. Azimova

I.M. Sechenov Moscow Medical Academy, Moscow

Author for correspondence.
Email: platonova@neurology.ru
Russian Federation

G. R. Tabeeva1

I.M. Sechenov Moscow Medical Academy, Moscow

Email: platonova@neurology.ru
Russian Federation

E. A. Klimov

N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow

Email: platonova@neurology.ru
Russian Federation

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Copyright (c) 2008 Azimova J.E., Tabeeva1 G.R., Klimov E.A.

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