Peculiarities of painful stress after neurotensin administrations in rats with toxic damage of serotoninergic brain structures
- Authors: Shugalev N.P.1, Stavrovskaya A.V.1, Ol’shansky A.S.1, Yamshikova N.G.1, Kalinovich E.V.1
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Affiliations:
- Research Center of Neurology
- Issue: Vol 1, No 4 (2007)
- Pages: 23-34
- Section: Original articles
- Submitted: 07.02.2017
- Published: 14.02.2017
- URL: https://annaly-nevrologii.com/journal/pathID/article/view/420
- DOI: https://doi.org/10.17816/psaic420
- ID: 420
Cite item
Full Text
Abstract
The purpose of this study was to elucidate the influence of neurotensin on realization of locomotor reactions of passive avoidance and painful stress after actions in rats with lesion of serotoninergic brain structures. It was shown that administration of selective neurotoxin, 5,7 dihydroxytryptamine, into raphe dorsalis nucleus enhanced, while administration into substantia nigra, on the contrary, weakened reproduction of passive defence reactions at rats. In painful stress after action the neurotoxin administration into the specified brain formations caused differentdirected changes of locomotor activity of rats and its behaviour in the elevated Xmaze. Neurotensin microinjections into substantia nigra and nuclei caudatus weakened neurotensin effects and, thus, increased adaptive character of defensive behaviour in rats with deficit of serotoninergic neuron function. Alleviation, by neurotensin, of negative influence of painful stress on animal behaviour can be manifestation of anx iolitic properties of this neuropeptide and specify its protective role in emotional stress.
About the authors
N. P. Shugalev
Research Center of Neurology
Email: alla_stav@mail.ru
Russian Federation, Moscow
Alla V. Stavrovskaya
Research Center of Neurology
Author for correspondence.
Email: alla_stav@mail.ru
ORCID iD: 0000-0002-8689-0934
Cand. Sci. (Biol.), leading researcher, Laboratory of experimental pathology of the nervous system
Russian Federation, MoscowArtyem S. Ol’shansky
Research Center of Neurology
Email: alla_stav@mail.ru
Russian Federation, Moscow
Nina G. Yamshikova
Research Center of Neurology
Email: alla_stav@mail.ru
Russian Federation, Moscow
E. V. Kalinovich
Research Center of Neurology
Email: alla_stav@mail.ru
Russian Federation, Moscow
References
- Дубровина Н.И., Попова Е.В., Ильюченок Р.Ю. Компенсаторно- восстановительные эффекты квинпирола при угашении условного навыка и амнезии у мышей с альтернативными стереотипами поведения. Эксперим. клин. фармакология 2001; 64: 13–16.
- Исмайлова Х.Ю., Семенова Т.П., Искандерова М.Д., Фаст А.Е. Особенности влияния тафцина на поведение и на уровень биогенных аминов мозга крыс с различной устойчивостью к акустическому стрессу. Журн. высш. нервн. деят. 1998; 48: 1043–1050.
- Молодцова Г.Ф. Различная роль дофамина и сертонина в процессе воспроизведения условной реакции пассивного избегания у крыс. Журн. высш. нервн. деят. 2006; 56: 242–246.
- Ставровская А.В. Шугалев Н.П., Хартманн Г. О функциональном значении влияния нейротензина на серотонинергические структуры мозга. В сб.: Структурно-функциональные и нейрохимические закономерности асимметрии и пластичности мозга. М., 2005: 262–265.
- Федотова Ю.О., Сапронов Н.С. Поведенческие эффекты L-триптофана и р-хлорфенилаланина после адреналэктомии или введения дексаметазона у крыс. Журн. высш. нервн. деят. 2002; 52: 609–617.
- Шугалев Н.П., Ставровская А.В., Ольшанский А.С. и др. О серотонинергических механизмах влияния нейротензина на поведения пассивного избегания у крыс. Журн. высш. нервн. деят. 2007; 57: 341–346.
- Шугалев Н.П., Хартманн Г., Кертеш Е. Последействие микроинъекций нейротензина в черную субстанцию мозга на условные двигательные реакции крыс с повреждением серотонинергических нейронов. Журн. высш. нервн. деят. 2003; 53: 802–807.
- Argyropoulos S.V., Sandford J.J., Nutt D.J. The psychobiology of anxiolytic drug. Part 2: pharmacological treatments of anxiety. Pharmacol Ther. 2000; 88: 213–227.
- Binder E.B., Kinkead B., Owens M.J. et al. Neurotensin and dopamine interactions. Parmacol. Rev. 2001; 53: 453–456.
- Corley K.S., Phan T.H., Daugherty W.P. et al. Stress indused activation of median raphe serotoninergic neurons in rats is potentiated by neurotensin antagonist, SR48692. Neurоsci. Lett. 2002; 319: 1–14.
- Dilts R.P., Novitzki M.R., Phan T.H. et al. Neurotensin inhibits the activation of midbrain serotoninergic neurons produced by random inescapable sound. Brain Res. 1996; 742: 294–298.
- Fassio A., Evans G., Grisshammer R. et al. Distribution of neurotensin receptor NTS1 in the rat CNS studied using an amino-terminal directed antibody. Neuropharmacology 2000; 39: 1430–1442.
- Fuxe K., O’Connor W., Antonelli T. Evidence for substrate of neuronal plasticity based on pre- and postsynaptic neurotensin-dopamine receptor interaction in the neostriatum. Proc. Nat. Acad. Sci. USA, 1992; 89: 5591–5594.
- Graeff F.G. On serotonin and experimental anxiety. Psychopharmacology 2002; 163: 467–476.
- Grahn R., Will M., Hammack S. Activation of serotonin immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor. Brain Res. 1999; 826: 35–43.
- Jennes L., Stumpf W.E., Kalivas P.W. Neurotensin: topographical distribution in rat brain by immunohistochemestry. J. Comp. Neurol. 1982; 210: 211–224.
- Jolash T., Aghajanian G.K. Neurotensin and the serotoninergic system. Progr. Neurobiol. 1997; 52: 455–458.
- Jolicoeur F.B., Gagne M.A., Rivest R. et al. Atypical effect-like behavioral of neurotensin. Brain Res. Bul. 1993; 32: 487–491.
- Landuron P.M. Functional concequences of retrograde axonal transport of receptor-bound neurotensin. Trends Pharmacol. Sci. 1995; 16: 338–343.
- Levant B., Nemeroff C.B. Futher studies on the modulation of regional brain neurotensin concentration by antipsychotic drugs: focus on haloperidol and BMY 14802. J. Pharmacol. Exp. Therap. 1992; 262: 348–355.
- Rompre P.P. Psychostimulant-like effect of central microinjection of neurotensin on brain stimulation reward. Peptides 1995; 16: 1417–1420.
- Shi W.X., Bunney B.S. Effects of neurotensin on midbrain dopamine neurones: are they mediated by formation of neurotensin-dopamine complex. Synapse 1991; 9: 157–164.
- Wang Q.P., Guan J.L., Nakai Y. Synaptic relations of neurotensinergic neurons in dorsal raphe nucleus. Peptides 1995; 16: 1421–1427.
- Werkman T.R., Kruse C.G., Nievelstein H. et al. Neurotensin attenuates the quinpirol-induced inhibition of the firing rate of dopamine neurons in the rat substantia nigra pars compacta and the ventral tegmental area. Neuroscience 2000; 95: 417–423.