Peculiarities of painful stress after neurotensin administrations in rats with toxic damage of serotoninergic brain structures

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The purpose of this study was to elucidate the influence of neurotensin on realization of locomotor reactions of passive avoidance and painful stress after actions in rats with lesion of serotoninergic brain structures. It was shown that administration of selective neurotoxin, 5,7 dihydroxytryptamine, into raphe dorsalis nucleus enhanced, while administration into substantia nigra, on the contrary, weakened reproduction of passive defence reactions at rats. In painful stress after action the neurotoxin administration into the specified brain formations caused differentdirected changes of locomotor activity of rats and its behaviour in the elevated Xmaze. Neurotensin microinjections into substantia nigra and nuclei caudatus weakened neurotensin effects and, thus, increased adaptive character of defensive behaviour in rats with deficit of serotoninergic neuron function. Alleviation, by neurotensin, of negative influence of painful stress on animal behaviour can be manifestation of anx iolitic properties of this neuropeptide and specify its protective role in emotional stress.

About the authors

N. P. Shugalev

Research Center of Neurology

Russian Federation, Moscow

Alla V. Stavrovskaya

Research Center of Neurology

Author for correspondence.
ORCID iD: 0000-0002-8689-0934

Cand. Sci. (Biol.), leading researcher, Laboratory of experimental pathology of the nervous system

Russian Federation, Moscow

Artyem S. Ol’shansky

Research Center of Neurology

Russian Federation, Moscow

Nina G. Yamshikova

Research Center of Neurology

Russian Federation, Moscow

E. V. Kalinovich

Research Center of Neurology

Russian Federation, Moscow


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Copyright (c) 2007 Shugalev N.P., Stavrovskaja A.V., Olshanskij A.S., Yamshikova N.G., Kalinovich E.V.

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