Metabolic syndrome and ischemic stroke

Abstract

Metabolic syndrome is multifactorial (hyperinsulinaemia, arterial hypertension, dyslipidaemia, obesity) condition with the increased risk of cerebrovascular diseases. In the majority of cases it is associated with its influence on the system оf haemorrheology and haemostasis. In our study we investigated two groups of patients with ischemic stroke: 20 with and 20 without metabolic syndrome. Patients with metabolic syndrome had slower recovery and worse outcome after stroke compared to patients without metabolic syndrome. It was showed that metabolic syndrome makes worse common macro and microrheological blood parameters: increases thrombocyte and erythrocyte aggregation, decreases erythrocyte deformability. The exhaustion of all components of atherombogenic (antiaggregation, anticoagulation and fibrinolytic) potential of the vessels’ wall was also demonstrated. All revealed changes stimulate forming of thrombi and make worse microcirculation in patients with metabolic syndrome. The monitoring of haemorrheological and haemostatic parameters is essential for improving of the treatment of patients with ischemic stroke, especially patients with metabolic syndrome background.

About the authors

M. M. Tanashyan

Research Center of Neurology

Author for correspondence.
Email: platonova@neurology.ru
Russian Federation

S. V. Orlov

Research Center of Neurology

Email: platonova@neurology.ru
Russian Federation

M. A. Domashenko

Research Center of Neurology

Email: platonova@neurology.ru
Russian Federation

V. G. Ionova

Research Center of Neurology

Email: platonova@neurology.ru
Russian Federation

References

  1. Альтшулер М.Ю. Метаболический синдром – особенности инсулиновой секреции и механизмы формирования атеротромбогенного потенциала. Дис. … докт. мед. наук, 2002.
  2. Балуда В.П., Деянов И.И., Балуда М.В. и др. Профилактика тромбозов. / Под ред. В.П. Балуды. Саратов: Изд. Саратовского ун-та, 1992.
  3. Дисфункция эндотелия. Причины, механизмы, фармакологическая коррекция. / Под ред. проф. Н.Н. Петрищева. СПб.: Изд. С.-Петерб. гос. мед. ун-та им. акад. И.П. Павлова, 2003.
  4. Домашенко М.А. Дисфункция эндотелия в остром периоде ишемического инсульта. Дис. … канд. мед. наук, 2006.
  5. Климов А.Н., Никуличева Н.Г. Обмен липидов и липопротеидов и его нарушения. СПб.: Питер, 1999.
  6. Мамедов М.Н., Шальнова С.А., Оганов Р.Г. Итоги III Всероссийской научно-практической конференции «Актуальные вопросы диагностики и лечения метаболического синдрома». Кардиология 2007; 5: 87–88.
  7. Панченко Е.П., Добровольский А.Б. Тромбозы в кардиологии. Механизмы развития и возможности терапии. М.: Изд. Ин-та кардиологии им. А.Л. Мясникова РКНПК МЗ РФ, 1999.
  8. Суслина З.А., Пирадов М.А., Танашян М.М. Принципы лечения острых ишемических нарушений мозгового кровообращения. В кн.: Очерки ангионеврологии. / Под ред. З.А. Суслиной. М.: Атмосфера, 2005.
  9. Суслина З.А., Танашян М.М., Ионова В.Г. Ишемический инсульт: кровь, сосудистая стенка, антитромботическая терапия. М.: Медицинская книга, 2005.
  10. Чазова И.Е., Мычка В.Б. Метаболический синдром и артериальная гипертония. Consilium medicum 2002; 11: 587–590.
  11. Aloulou I., Varlet Marie E., Mercier J., Brun J.F. Hemorheologic effects of low intensity endurance training in sedentary patients suffering from the metabolic syndrome. Clin. Hemorheol. Microcirc. 2006; 35 (1-2): 333–339.
  12. Brun J.F., Aloulou I., Varlet Marie E. Hemorheological aspects of the metabolic syndrome: markers of insulin resistance, obesity or hyperinsulinemia? Clin. Hemorheol. Microcirc. 2004; 30 (3-4): 203–209.
  13. European guidelines on cardiovascular disease prevention in clinical practice. Third joint task force of European and other societies in cardiovascular disease prevention in clinical practice. Eur. Heart. J. 2003; 24: 1601–1610.
  14. Iso H., Sato S., Kitamura A. et al. The risk of ischemic heart disease and stroke among Japanese men and women. Stroke 2007; 38: 1744–1751.
  15. Kurl S., Laukkanen J.A., Niskanen L. et al. Metabolic syndrome and the risk of stroke in middle-aged men. Stroke 2006; Mar. 37 (3): 806–811.
  16. Lo Presti R., Sinagra D., Montana M. et al. Haemorheological profile in metabolic Syndrome. Clin. Hemorheol. Microcirc. 2002; 26 (4): 241–247.
  17. McNeil A.M., Schmidt M.I., Rosamond W.D. et al. The metabolic syndrome and 11№year risk of incident cardiovascular disease in the atherosclerosis risk in communities study. Diabetes Care 2005; 28: 385–390.
  18. Multicenter trial of hemodilution in ischemic stroke-background and study protocol. / Scandinavian Stroke Study Group. Stroke 1985; 16: 885–890.
  19. Reaven G.M. Banting Lecture 1988. Role of insulin resistance inhuman disease. Diabetes 1988; 37: 1595–1607.
  20. World Health Organization. Definition, diagnosis and classification of diabetes mellitus and its complications: Report of a WHO consultation. Geneva, Switzerland: WHO, 1999. Available at: Accessed December 12, 2003.

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Copyright (c) 2017 Tanashyan M.M., Orlov S.V., Domashenko M.A., Ionova V.G.

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