Influence of rehabilitation therapy on functional organization of motor systems after stroke

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Abstract

Functional MRI (fMRI) was applied to study mechanisms of unctional reorganization of motor systems after ischemic stroke (IS) as the result of rehabilitation. Two groups of patients with IS were recruited: 16 patients on standard restorative therapy (basic group) and 16 patients on functional training – EMG biofeedback (comparison group). In addition, functional training was given to 14 healthy individuals (normal control). In controls, an increase in signal intensity from main activation zones and appearance of characteristic additional activation zones in cerebellar hemispheres, corpus callosum and premotor cortex was noted. In patients after basic rehabilitation, an increase in signal intensity from main activation zones in sensorimotor area and cerebellar hemispheres was revealed for both affected and nonaffected hand, irrespective of IS localization. In patients after functional training, the reorganization of functional motor system consisted in an increase in signal intensity of main activation zones only in the ipsilesional hemisphere; expressiveness of these changes did not depend on IS localization. The degree of motor recovery of the hand after functional training was significantly higher than after the basic course of rehabilitation therapy. So, neuroimaging (fMRI) and clinical analysis showed directional and effective influence of the functional training method on the processes of motor system reorganization.

About the authors

S. N. Busheneva

Research Center of Neurology

Author for correspondence.
Email: platonova@neurology.ru
Russian Federation

A. S. Kadykov

Research Center of Neurology

Email: platonova@neurology.ru
Russian Federation

L. A. Chernikova

Research Center of Neurology

Email: platonova@neurology.ru
Russian Federation

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Copyright (c) 2007 Busheneva S.N., Kadykov A.S., Chernikova L.A.

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