Morphological and functional assessment of the effect of L-lysine aescinat in rats with experimental ischemia of the spinal cord

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Abstract

Background. Spinal cord ischemia (SCI) is accompanied by severe persistent neurological and physical disorders. The article discusses potential neuroprotective effect of L-lysine aescinat.
Objective. to assess the effect of L-lysine aescinat on the functional recovery and morphological picture of spinal cord in white rats with simulated SCI.
Methods. Spinal cord ischemia was induced by ligation of the infrarenal abdominal aorta in two experimental groups of rats. In the control group (n=8), aorta was ligated; in the experimental group (n=8), L-lysine aescinat was injected intraperitoneally at a dose of 0.14 mg/kg 30 minutes before ischemia, followed by ligation of aorta.
Results. Pronounced and statistically significant neuroprotective effect of L-lysine aescinat was demonstrated, which clinically manifested as neurological deficit reduction and morphologically manifested as increased number of normochromic neurons and decreased number of shrunken neurons and shadow-cells (p<0.01), as well as suppression of edema of the spinal cord substance.
Conclusion. L-lysine aescinat has a neuroprotective effect in rats with experimental ischemia of the spinal cord.

About the authors

G. V. Ponomarev

I.P. Pavlov First Saint-Petersburg State Medical University, Ministry of Health of the Russian Federation, St. Petersburg

Author for correspondence.
Email: platonova@neurology.ru
Russian Federation

A. A. Shmonin

I.P. Pavlov First Saint-Petersburg State Medical University, Ministry of Health of the Russian Federation, St. Petersburg

Email: platonova@neurology.ru
Russian Federation

A. G. Shumeeva

I.P. Pavlov First Saint-Petersburg State Medical University, Ministry of Health of the Russian Federation, St. Petersburg

Email: platonova@neurology.ru
Russian Federation

K. T. Aliyev

I.P. Pavlov First Saint-Petersburg State Medical University, Ministry of Health of the Russian Federation, St. Petersburg

Email: platonova@neurology.ru
Russian Federation

T. D. Vlasov

I.P. Pavlov First Saint-Petersburg State Medical University, Ministry of Health of the Russian Federation, St. Petersburg

Email: platonova@neurology.ru
Russian Federation

E. V. Mel’nikova

ГБОУ ВПО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России

Email: platonova@neurology.ru
Russian Federation

A. A. Skoromets

V.A. Almazov North-West Federal Medical Research Center, Ministry of Health of the Russian Federation, St. Petersburg

Email: platonova@neurology.ru
Russian Federation

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Copyright (c) 2017 Ponomarev G.V., Shmonin A.A., Shumeeva A.G., Aliyev K.T., Vlasov T.D., Mel’nikova E.V., Skoromets A.A.

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