Quantitative sonographic parameters of the peripheral nerves in healthy individuals

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Introduction. Ultrasonography allows non-invasive scanning of the peripheral nerves to record quantitative and qualitative parameters.

Objective. To determine the normal cross-sectional area (CSA) of the nerves in arms and legs, as well as spinal nerves in healthy volunteers.

Materials and methods. Bilateral ultrasonography of the peripheral nerves in arms and legs, as well as the spinal nerves in the brachial plexus was carried out in healthy volunteers: 40 males and 40 females with the mean age of 40.3±15.1 (range, 18–70 years). A Sonoscape S20 ultrasound scanner (China) with an 8–15 MHz linear sensor. The cross-sectional area of the peripheral nerves was assessed. Height, weight, the body mass index (BMI), age, and gender were included in analysis.

Results. The reference CSA values for the major nerves of arms, legs, and spinal nerves of the brachial plexus were obtained. No reliable correlation of the main anthropometric parameters (height, weight, and BMI) as well as age and gender with the CSA of the peripheral nerves and the brachial plexus was found.

Conclusions. The findings are in accordance with the measured parameters reported by other authors, indicating that our methodological approach to nerve ultrasonography is similar to those used in other laboratories.

About the authors

Eugenia S. Naumova

Clinics “Practical Neurology”

Author for correspondence.
Email: naumovaes@gmail.com
Russian Federation, Moscow

Sergey S. Nikitin

Regional public organization “Association for Neuromuscular Diseases”; Clinics “Practical Neurology”

Email: naumovaes@gmail.com
Russian Federation, Moscow

Dmitry S. Druzhinin

Yaroslavl State Medical University

Email: naumovaes@gmail.com
Russian Federation, Yaroslavl


  1. Solbiati L., De Pra L., Ierace T. et al. High-resolution sonography of the recurrent laryngeal nerve: anatomic and pathologic considerations. AJR Am J Roentgenol. 1985; 145: 989–993. PMID: 3901711; doi: 10.2214/ajr.145.5.989.
  2. Fornage B.D. Peripheral nerves of the extremities: imaging with US. Radiology. 1988; 167(1): 179–182. PMID: 3279453; doi: 10.1148/radiology.167.1.3279453.
  3. Es'kin N.A., Golubev V.G., Bogdashevskiy D.R. et al. [Sonography of the nerves, tendons and ligaments]. Sono Ace International. 2005. 13: 82–94. (In Russ.).
  4. Mironov S.P., Es'kin N.A., Golubev V.G. et al. [Ultrasound diagnosis of pathology of the tendons and nerves of limbs]. Bulletin of traumatology and orthopedics. 2004. 3: 3–4. (In Russ.).
  5. Boehm J., Scheidl E., Bereczki D. et al. Нigh-resolution ultrasonography of peripheral nerves: measurements on 14 nerve segments in 56 healthy subjects and reliability assessments. Ultraschall Med 2014; 35: 459–467. PMID: 24764211; doi: 10.1055/s-0033-1356385.
  6. Cartwright M., Passmore L., Yoon J. et al. Cross-sectional area reference values for nerve ultrasonography. Muscle Nerve 2008; 37: 566–571. PMID: 18351581; doi: 10.1002/mus.21009.
  7. Zaidman C., Al-Lozi M., Pestronk A. Peripheral nerve size in normals and patients with polyneuropathy: an ultrasound study. Muscle Nerve 2009; 40: 960–966. PMID: 19697380; doi: 10.1002/mus.21431.
  8. Qrimli M., Ebadi H., Breiner A. et al. Reference values for ultrasonograpy of peripheral nerves. Muscle Nerve. 2016; 53(4): 538–544. PMID: 26316047; doi: 10.1002/mus.24888
  9. Haun D.W., Cho J.C., Kettner N.W. Normative cross-sectional area of the C5-C8 nerve roots using ultrasonography. Ultrasound Med Biol. 2010; 36(9): 1422–1430. PMID: 20800169; doi: 10.1016/j.ultrasmedbio.2010.05.012.
  10. Bathala L., Kumar P., Kumar K. et al. Normal values of median nerve cross-sectional area obtained by ultrasound along its course in the arm with electrophysiological correlations, in 100 Asian subjects. Muscle Nerve. 2014; 49(2): 284–286. PMID: 23703739; doi: 10.1002/mus.23912.
  11. Yalcin E., Onder B., Akyuz M. Ulnar nerve measurements in healthy individuals to obtain reference values, Rheumatol Int. 2013; 33(5): 1143–1147. PMID: 22948543; doi: 10.1007/s00296-012-2527-9.
  12. Chen J., Wu S., Ren J. Ultrasonography reference values for assessing normal radial nerve ultrasonography in the normal population. Neural Regen Res. 2014 15; 9(20): 1844–1849. PMID: 25422648; doi: 10.4103/1673-5374.143433.
  13. Won S., Kim B., Park K. et al. Measurement of cross-sectional area of cervical roots and brachial plexus trunks. Muscle Nerve. 2012; 46(5): 711–716. PMID: 23055312; doi: 10.1002/mus.23503.
  14. Seok H.Y., Jang J.H., Won S.H. et al. Cross-Sectional Area Reference Values of Nerves in the Lower Extremities Using Ultrasonography. Muscle Nerve 50: 564–570, 2014. PMID: 24639103; doi: 10.1002/mus.24209.
  15. Sugimoto T., Ochi K., Hosomi N. et al. Ultrasonography reference sizes of the median and ulnar nerves and the cervical nerve roots in healthy Japanese adults. Ultrasound Med Biol 2013; 39: 1560–1570. PMID: 23830101; doi: 10.1016/j.ultrasmedbio.2013.03.031.
  16. Cartwright M.S., DeMar S., Griffith L.P. et al. Validity and reliability of nerve and muscle ultrasound. Muscle Nerve 2013; 47: 515–521. PMID: 23400913; doi: 10.1002/mus.23621.
  17. Kerasnoudis A., Pitarokoili K., Behrendt V. et al. Cross sectional area reference values for sonography of peripheral nerves and brachial plexus. Clin Neurophysiol. 2013; 124(9): 1881–1888. PMID: 23583024; DOI: 10.1016/j. clinph.2013.03.007.

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Copyright (c) 2017 Naumova E.S., Nikitin S.S., Druzhinin D.S.

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