Clinical heterogeneity of progressive supranuclear palsy

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Abstract

Progressive supranuclear palsy (PSP) is a sporadic neurodegenerative disease characterized by oculomotor disorders, early onset of postural instability and cognitive dysfunction. Classic form of the disease (Richardson’s syndrome) develops only in 24% of all cases, while other phenotypes are registered in most patients. Clinical manifestations of the various types the PSP, as well as their similarities and differences with other nosological forms of extrapyramidal disorders are described in the current review. New diagnostic criteria of PSP developed by the International Society for the Parkinson's Disease and Movement Disorders in 2017 are discussed. Two clinical cases of PSP in patients of Yakhut ethnic origin are presented: in the first case there was classical variant of the disease (Richardson’s syndrome), and in the second case – a PSP-parkinsonism variant.

About the authors

Alexey A. Tappakhov

M.K. Ammosov North-Eastern Federal University

Author for correspondence.
Email: govorovatatyana@mail.ru
Russian Federation, Yakutsk

Tatiana E. Popova

M.K. Ammosov North-Eastern Federal University

Email: govorovatatyana@mail.ru
ORCID iD: 0000-0003-1062-1540

D. Sci. (Med.), Deputy director for science

Russian Federation, Yakutsk

Tatiana G. Govorova

M.K. Ammosov North-Eastern Federal University

Email: govorovatatyana@mail.ru
ORCID iD: 0000-0003-0610-3660

postgraduate student, Department of neurology and psychiatry, Head, Laboratory of neuropsychophysiological research, Medical Institute

Russian Federation, Yakutsk

Alyona Yu. Petrova

Republican Hospital No. 2 — The center of the Emergency Medical Care

Email: govorovatatyana@mail.ru

neurologist, Department of neurology

Russian Federation, Yakutsk

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Copyright (c) 2018 Tappakhov A.A., Popova T.E., Govorova T.G., Petrova A.Y.

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