Progressive multifocal leukoencephalopathy as a complication of disease-modifying treatment of multiple sclerosis

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Abstract

The review provides modern understanding of the pathogenesis of progressive multifocal leukoencephalopathy (PML), a severe and potentially fatal form of multiple-lesion disorder of the brain white matter. Information about the frequency of its development in patients with disease-modifying treatment of multiple sclerosis is analyzed. The algorithms of optimization of PML risks in this category of patients with multiple sclerosis are described in detail. Summarized are the data on most significant PML biomarkers, the search for which is currently under way in many centers across the world. The first case of PML in Russia is briefly described.

About the authors

Maria N. Zakharova

Research Center of Neurology

Email: Lysogorskaya@neurology.ru
Russian Federation, Moscow

Elena V. Lysogorskaia

Research Сenter of Neurology

Author for correspondence.
Email: Lysogorskaya@neurology.ru
Russian Federation, Moscow

Maria V. Ivanova

Research Сenter of Neurology

Email: Lysogorskaya@neurology.ru
Russian Federation, Moscow

Ivan А. Kochergin

Research Сenter of Neurology

Email: Lysogorskaya@neurology.ru
Russian Federation, Moscow

Yulia E. Korzhova

Research Сenter of Neurology

Email: Lysogorskaya@neurology.ru
Russian Federation, Moscow

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Copyright (c) 2018 Zakharova M.N., Lysogorskaia E.V., Ivanova M.V., Kochergin I.А., Korzhova Y.E.

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