Clinical features and mechanisms of the development of cognitive impairment in children with obstructive sleep apnoea syndrome

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Abstract

The article reviews clinical features and mechanisms of the development of cognitive impairment in children with obstructive sleep apnoea/hypopnea syndrome (OSAHS). Short-term and long-term consequences of sleep apnoea along with the pathogenetic similarity of OSAHS and neurodynamic disturbances and concomitant conditions are discussed. The role of ENT conditions in children with OSAHS is reviewed as well. Data on the genetic features that affect the risk of developing OSAHS in children are presented.

About the authors

Tatyana P. Kalashnikova

Academician E.A. Vagner Perm State Medical University, Perm

Author for correspondence.
Email: platonova@neurology.ru
Russian Federation

Anna V. Yastrebova

Academician E.A. Vagner Perm State Medical University, Perm

Email: platonova@neurology.ru
Russian Federation

References

  1. Guilleminault C., Connolly S., Winkle R. Cardiac arrhythmia and conduction disturbances during sleep in 400 patients with sleep apnea syndrome. Am J Cardiol 1983; 52(5): 490–494. doi: 10.1016/0002-9149(83)90013-9. PMID: 6193700.
  2. Rosenberg R.S., Van Hout S. The American Academy of Sleep Medicine Inter-scorer Reliability program: respiratory events. J Clin Sleep Med 2014; 10(4): 447–454. doi: 10.5664/jcsm.3630. PMID: 24733993.
  3. Memon J., Manganaro S.N. Obstructive sleep-disordered breathing (SDB). 2019. PMID: 28722938.
  4. Zhou J., Camacho M., Tang X., Kushida C. A review of neurocognitive function and obstructive sleep apnea with or without daytime sleepiness. Sleep Med 2016; 23: 99–108. doi: 10.1016/j.sleep.2016.02.008. PMID: 27288049.
  5. Ferini-Strambi L., Lombardi G.E., Marelli S., Galbiati A. Neurological deficits in obstructive sleep apnea. Curr Treat Options Neurol 2017; 19(4): 16. doi: 10.1007/s11940-017-0451-8. PMID: 28374233.
  6. Cheng S., Stark C.D., Stark R.J. Sleep apnoea and the neurologist. Pract Neurol 2017; 17(1): 21–27. doi: 10.1136/practneurol-2016-001524. PMID: 27974377.
  7. Nanthakumar S., Bucks R., Skinner T. et al. Assessment of the Depression, Anxiety, and Stress Scale (DASS-21) in untreated obstructive sleep apnea (OSA). Psychol Assess 2017; 29(10): 1201–1209. doi: 10.1037/pas0000401. PMID: 27936819.
  8. Stark C.D., Stark R.J. Sleep and chronic daily headache. Curr Pain Headache Rep 2015; 19(1): 468. doi: 10.1007/s11916-014-0468-6. PMID: 25416461.
  9. Chien Y.H., Guilleminault C. [Historical review on obstructive sleep apnea in children]. Arch Pediatr 2017; 24(Suppl 1): S2–S6. doi: 10.1016/j.arcped.2016.10.017. PMID: 27908527. (In French.)
  10. Licis A. Sleep disorders: assessment and treatment in preschool-aged children. Child Adolesc Psychiatr Clin N Am 2017; 26(3): 587–595. doi: 10.1016/j.chc.2017.02.009. PMID: 28577611.
  11. Landau Y.E., Bar-Yishay O., Greenberg-Dotan S. et al. Impaired behavioral and neurocognitive function in preschool children with obstructive sleep apnea. Pediatr Pulmonol 2012; 47(2): 180–188. doi: 10.1002/ppul.21534. PMID: 21905262.
  12. Idiazábal-Alecha M.Á., Fernández-Prats M. [Sleep-disordered breathing in early childhood: their neurocognitive repercussions]. Rev Neurol 2014; 58(Suppl 1): S83–S88. PMID: 25252673. [In Spanish.]
  13. Daurat A., Sarhane M., Tiberge M. [Obstructive sleep apnea syndrome and cognition: A review]. Neurophysiol Clin 2016; 46(3): 201–215. doi: 10.1016/j.neucli.2016.04.002. PMID: 27321089. [In French.]
  14. Devita M., Montemurro S., Ramponi S. et al. Obstructive sleep apnea and its controversial effects on cognition. J Clin Exp Neuropsychol 2017; 39(7): 659–669. doi: 10.1080/13803395.2016.1253668. PMID: 27845600.
  15. Dewan N., Nieto F., Somers V. Intermittent hypoxemia and OSA: implications for comorbidities. Chest 2015; 147(1): 266–274. doi: 10.1378/chest.14-0500. PMID: 25560865.
  16. Constantin E., Low N.C., Dugas E. et al. Association between childhood sleep-disordered breathing and disruptive behavior disorders in childhood and adolescence. Behav Sleep Med 2015; 13(6): 442–454. doi: 10.1080/15402002.2014.940106. PMID: 25102357.
  17. Sedky K., Bennett D.S., Carvalho K.S. Attention deficit hyperactivity disorder and sleep disordered breathing in pediatric populations: a meta-analysis. Sleep Med Rev 2014; 18(4): 349–356. doi: 10.1016/j.smrv.2013.12.003. PMID: 24581717.
  18. Huang Y., Guilleminault C., Li H. et al. Attention-deficit/hyperactivity disorder with obstructive sleep apnea: a treatment outcome study. Sleep Med 2007; 8(1): 18–30. doi: 10.1016/j.sleep.2006.05.016. PMID: 17157096.
  19. Kalashnikova T.P., Anisimov G.V. [The clinical and polysomnographic characteristics of obstructive sleep apnea syndrome in the children]. Vestn Otorinolaringol 2014; (4): 42–45. PMID: 25377677. (In Russ.)
  20. McNally K.A., Shear P.K., Tlustos S. et al. Iowa gambling task performance in overweight children and adolescents at risk for obstructive sleep apnea. J Int Neuropsychol Soc 2012; 18(3): 481–489. doi: 10.1017/S1355617711001937. PMID: 22300670.
  21. Daurat A., Ricarrère M., Tiberge M. Decision making is affected in obstructive sleep apnoea syndrome. J Neuropsychol 2013; 7(1): 139–144. doi: 10.1111/j.1748-6653.2012.02039. PMID: 23088593.
  22. Madaeva I., Berdina O., Polyakov V., Kolesnikov S. Obstructive sleep apnea and hypertension in adolescents: effect on neurobehavioral and cognitive functioning. Can Respir J 2016; 2016: 3950914. doi: 10.1155/2016/3950914. PMID: 27445534.
  23. Caspari S.S., Strand E.A., Kotagal S., Bergqvist C. Obstructive sleep apnea, seizures, and childhood apraxia of speech. Pediatr Neurol 2008; 38(6): 422–425. doi: 10.1016/j.pediatrneurol.2008.03.002. PMID: 18486825.
  24. Hill C.M., Bucks R.S., Kennedy C.R. et al. Hearing loss mediates executive function impairment in sleep-disordered breathing. Sleep Med 2017; 34: 18–23. doi: 10.1016/j.sleep.2017.02.008. PMID: 28522090.
  25. Cellini N. Memory consolidation in sleep disorders. Sleep Med Rev 2017; 35: 101–112. doi: 10.1016/j.smrv.2016.09.003. PMID: 27765468.
  26. Kumar R., Chavez A.S., Macey P.M. et al. Altered global and regional brain mean diffusivity in patients with obstructive sleep apnea. J Neurosci Res 2012; 90(10): 2043–2052. doi: 10.1002/jnr.23083. PMID: 22715089.
  27. Yaouhi K., Bertran F., Clochon P. et al. A combined neuropsychological and brain imaging study of obstructive sleep apnea. J Sleep Res 2009; 18(1): 36–48. doi: 10.1111/j.1365-2869.2008.00705. PMID: 19250174.
  28. Lim D.C., Pack A.I. Obstructive sleep apnea and cognitive impairment: addressing the blood-brain barrier. Sleep Med Rev 2014; 18(1): 35–48. doi: 10.1016/j.smrv.2012.12.003. PMID: 23541562.
  29. Thomas R.J., Rosen B.R., Stern C.E. et al. Functional imaging of working memory in obstructive sleep-disordered breathing. J Appl Physiol (1985) 2005; 98(6): 2226–2234. doi: 10.1152/japplphysiol.01225.2004. PMID: 15677733.
  30. Castronovo V., Canessa N., Strambi L.F. et al. Brain activation changes before and after PAP treatment in obstructive sleep apnea. Sleep 2009; 32(9): 1161–1172. PMID: 19750921.
  31. Sangal R.B., Sangal J.M. Obstructive sleep apnea and abnormal P300 latency topography. Clin Electroencephalogr 1997; 28(1): 16–25. PMID: 9013046.
  32. Halbower A.C., Degaonkar M., Barker P.B. et al. Childhood obstructive sleep apnea associates with neuropsychological deficits and neuronal brain injury. PLoS Med 2006; 3(8): e301. doi: 10.1371/journal.pmed.0030301. PMID: 16933960.
  33. Lal C., Strange C., Bachman D. Neurocognitive impairment in obstructive sleep apnea. Chest 2012; 141(6): 1601–1610. doi: 10.1378/chest.11-2214. PMID: 22670023.
  34. Cha J., Zea-Hernandez J.A., Sin S. et al. The effects of obstructive sleep apnea syndrome on the dentate gyrus and learning and memory in children. J Neurosci 2017; 37(16): 4280–4288. doi: 10.1523/JNEUROSCI.3583-16.2017. PMID: 28320844.
  35. Beebe D.W., Gozal D. Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits. J Sleep Res 2002; 11(1): 11–16. doi: 10.1046/j.1365-2869.2002.00289. PMID: 1869421.
  36. Row B.W., Liu R., Xu W. et al. Intermittent hypoxia is associated with oxidative stress and spatial learning deficits in the rat. Am J Respir Crit Care Med 2003; 167(11): 1548–1553. doi: 10.1164/rccm.200209-1050OC. PMID: 12615622.
  37. Xu W., Chi L., Row B.W. et al. Increased oxidative stress is associated with chronic intermittent hypoxia-mediated brain cortical neuronal cell apoptosis in a mouse model of sleep apnea. Neuroscience 2004; 126(2): 313–323. doi: 10.1016/j.neuroscience.2004.03.055. PMID: 15207349.
  38. Ferini-Strambi L., Baietto C., Di Gioia M.R. et al. Cognitive dysfunction in patients with obstructive sleep apnea (OSA): partial reversibility after continuous positive airway pressure (CPAP). Brain Res Bull 2003; 61(1): 87–92. doi: 10.1016/S0361-9230(03)00068-6. PMID: 12788211.
  39. Nasr N., Traon A.P., Czosnyka M. et al. Cerebral autoregulation in patients with obstructive sleep apnea syndrome during wakefulness. Eur J Neurol 2009; 16(3): 386–391. doi: 10.1111/j.1468-1331.2008.02505. PMID: 19175381.
  40. Diekelmann S., Born J. The memory function of sleep. Nat Rev Neurosci 2010; 11(2): 114–126. doi: 10.1038/nrn2762. PMID: 20046194.
  41. Djonlagic I., Guo M., Matteis P. et al. First night of CPAP: impact on memory consolidation attention and subjective experience. Sleep Med 2015; 16(6): 697–702. doi: 10.1016/j.sleep.2015.01.017. PMID: 25953301.
  42. Nair D., Zhang S.X., Ramesh V. et al. Sleep fragmentation induces cognitive deficits via nicotinamide adenine dinucleotide phosphate oxidase-dependent pathways in mouse. Am J Respir Crit Care Med 2011; 184(11): 1305–1312. doi: 10.1164/rccm.201107-1173OC. PMID: 21868506.
  43. Entzian P., Linnemann K., Schlaak M., Zabel P. Obstructive sleep apnea syndrome and circadian rhythms of hormones and cytokines. Am J Respir Crit Care Med 1996; 153(3): 1080–1086. PMID: 8630548.
  44. Garcia J., Wical B., Wical W. et al. Obstructive sleep apnea in children with cerebral palsy and epilepsy. Dev Med Child Neurol 2016; 58(10): 1057–1062. doi: 10.1111/dmcn.13091. PMID: 26991829.
  45. Fan Z., Ahn M., Roth H.L. et al. Sleep apnea and hypoventilation in patients with Down syndrome: analysis of 144 polysomnogram studies. Children (Basel) 2017; 4(7): 55. doi: 10.3390/children4070055. PMID: 28665356.
  46. Canessa N., Castronovo V., Cappa S.F. et al. Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment. Am J Respir Crit Care Med 2011; 183(10): 1419–1426. doi: 10.1164/rccm.201005-0693OC. PMID: 21037021.
  47. O'Donoghue F.J., Wellard R.M., Rochford P.D. et al. Magnetic resonance spectroscopy and neurocognitive dysfunction in obstructive sleep apnea before and after CPAP treatment. Sleep 2012; 35(1): 41–48. doi: 10.5665/sleep.1582. PMID: 22215917.
  48. Castronovo V., Scifo P., Castellano A. et al. White matter integrity in obstructive sleep apnea before and after treatment. Sleep 2014; 37(9): 1465–1475. doi: 10.5665/sleep.3994. PMID: 25142557.
  49. Goldstein N.A., Gorynski M., Yip C. et al. Developmental delay in young children with sleep-disordered breathing before and after tonsil and adenoid surgery. Int J Pediatr Otorhinolaryngol 2016; 85: 107–111. doi: 10.1016/j.ijporl.2016.03.022. PMID: 27240507.
  50. Tran K.D., Nguyen C.D., Weedon J., Goldstein N.A. Child behavior and quality of life in pediatric obstructive sleep apnea. Arch Otolaryngol Head Neck Surg 2005; 131(1): 52–57. doi: 10.1001/archotol.131.1.52. PMID: 15655186.
  51. Yu Y., Chen Y.X., Liu L. et al. Neuropsychological functioning after adenotonsillectomy in children with obstructive sleep apnea: A meta-analysis. J Huazhong Univ Sci Technolog Med Sci 2017; 37(3): 453–461. doi: 10.1007/s11596-017-1756-2. PMID: 28585127.
  52. Taylor H.G., Bowen S.R., Beebe D.W. et al. Cognitive effects of adenotonsillectomy for obstructive sleep apnea. Pediatrics 2016; 138(2): e20154458. doi: 10.1542/peds.2015-4458. PMID: 27464674.

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Copyright (c) 2019 Kalashnikova T.P., astrebova A.V.

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