Bilateral hypertrophic olivary degeneration in genetic neurological disorders

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Abstract

Hypertrophic olivary degeneration (HOD) is a rare variant of transsynaptic degeneration in the inferior olivary nuclei due to a lesion within the dentato-rubro- olivary pathway, also known as the Guillain–Mollaret triangle. Bilateral HOD can be identified on MRI in patients with not only acquired but also genetic neurological disorders. The article describes patients with both common and rare genetic causes of the bilateral HOD. The pathophysiology of HOD is also briefly reviewed.

About the authors

Aleksander S. Suslin

Research Center of Neurology

Author for correspondence.
Email: suslin@neuroradiology.ru
Russian Federation, Moscow

Yury A. Seliverstov

Research Center of Neurology

Email: suslin@neuroradiology.ru
Russian Federation, Moscow

Elena I. Kremneva

Research Center of Neurology

Email: suslin@neuroradiology.ru
Russian Federation, Moscow

Marina V. Krotenkova

Research Center of Neurology

Email: suslin@neuroradiology.ru
Russian Federation, Moscow

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Copyright (c) 2020 Suslin A.S., Seliverstov Y.A., Kremneva E.I., Krotenkova M.V.

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