Venous thrombogenesis and functional state of the hemorheology and hemostasis system in stroke patients

Abstract

Comparison of the results of investigation of the hemorheology and hemostasis system in patients with stroke of various types, localization, and severity who were treated at critical and intensive care units, with venous thromboembolic complications (VTECs) and without VTEC, demonstrated a high significance of impairments in the hemorheology and hemostasis system for VTEC pathogenesis in stroke patients. Despite ongoing anticoagulant therapy, aggravation of the prothrombogenic state was observed in VTEC patients. Ischemic stroke was associated with more severe changes compared to hemorrhagic stroke. Hemostasiological predictors of VTEC were identified. In patients without VTEC, both the coagulation and anticoagulation systems as well as the fibrinolysis system were preserved. The D-dimer and thrombophilia markers, such as hyperhomocysteinemia and antiphospholipid syndrome, were shown not to contribute to the development of VTEC in stroke patients.

About the authors

Yu. V. Ryabinkina

Research Center of Neurology, Moscow

Author for correspondence.
Email: platonova@neurology.ru
Russian Federation

M. A. Piradov

Research Center of Neurology, Moscow

Email: platonova@neurology.ru
Russian Federation

M. M. Tanashyan

Research Center of Neurology, Moscow

Email: platonova@neurology.ru
Russian Federation

A. A. Shabalina

Research Center of Neurology, Moscow

Email: platonova@neurology.ru
Russian Federation

M. V. Kostyreva

Research Center of Neurology, Moscow

Email: platonova@neurology.ru
Russian Federation

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Copyright (c) 2017 Ryabinkina Y.V., Piradov M.A., Tanashyan M.M., Shabalina A.A., Kostyreva M.V.

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