Small fiber neuropathy

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Abstract

Despite the fact that small fiber neuropathy (SFN) has already been studied for 30 years, it remains one of the most mysterious diseases that are extremely difficult to diagnose and cure. The prevalence of SFN is 52.95 per 100,000 population; diabetes mellitus is considered to be the most frequent cause of this disease. Chronic neuropathic pain syndrome, temperature sensation abnormalities, and vegetative disorders develop as a result of damage to fine myelinated Аδ- and unmyelinated C fibers. The disease mainly spreads in the upward direction: from feet to the proximal body parts and arms; primary axonal damage takes place. Although SFN is believed to be one of the most “benign” neuropathy types as it does not affect the large sensory and motor fibers, it significantly decreases patients’ quality of life.

About the authors

Natalya A. Suponeva

Research Center of Neurology

Email: lagoda.d@neurology.ru
ORCID iD: 0000-0003-3956-6362

D. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, principal researcher, Department of neurorehabilitation and physiotherapy

Россия, Moscow

Natalia V. Belova

Research Center of Neurology

Author for correspondence.
Email: lagoda.d@neurology.ru
Россия, Moscow

Natalia I. Zaitseva

Lomonosov Moscow State University

Email: lagoda.d@neurology.ru
Россия, Moscow

Djamilya G. Yusupova

Research Center of Neurology

Email: lagoda.d@neurology.ru
ORCID iD: 0000-0002-5826-9112

neurologist, junior researcher, Department of neurorehabilitation and physiotherapy

Россия, Moscow

Dmitry Yu. Lagoda

Research Center of Neurology

Email: lagoda.d@neurology.ru
ORCID iD: 0000-0002-9267-8315

junior researcher, Department of neurorehabilitation and physiotherapy

Россия, Moscow

Olga S. Korepina

Research Center of Neurology

Email: lagoda.d@neurology.ru
Россия, Moscow

Mikhail A. Piradov

Research Center of Neurology

Email: lagoda.d@neurology.ru
ORCID iD: 0000-0002-6338-0392

D. Sci. (Med.), Professor, Full Member of the Russian Academy of Sciences, Director

Россия, Moscow

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Copyright (c) 2017 Suponeva N.A., Belova N.V., Zaitseva N.I., Yusupova D.G., Lagoda D.Y., Korepina O.S., Piradov M.A.

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