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Anesthetic neurotoxicity and intraoperative cerebral neuroprotectioan is one of the important issues in modern anesthesiology. General anesthesia, in addition to its hypnotic effect, is considered to cause postoperative cognitive dysfunction as a manifestation of encephalopathy. Narcosis based on propofol is a “gold standard” of total intravenous anesthesia and is frequently used for surgery in patients of various ages. This experimental study investigates the effects of propofol on neuronal population in hippocampus of immature rats. In propofol-anesthezied rats within 30 min of exposition, a two-fold increase of altered hippocampal neurons was detected compared to control animals, however no neuronal cell death was observed. Intraoperative use of ethylmethylhydroxypyridine succinate ameliorates propofol-induced neuronal damagethat proves a neuroprotective effect of the drug tested.
Influence of propofol on hippocampus in developing brain: an experimental study
- Authors: Lobov M.A.1, Dreval A.A.2, Ovezov A.M.1, Panteleeva M.V.1, Pashina N.R.2, Knyazev A.V.1, Borisova M.N.1, Lugovoy A.V.1
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Affiliations:
- Moscow Regional Scientific Research and Clinical Institute
- Russian Scientific Research Medical University
- Issue: Vol 7, No 3 (2013)
- Pages: 42-46
- Section: Original articles
- URL: https://annaly-nevrologii.com/journal/pathID/article/view/227
- DOI: https://doi.org/10.17816/psaic227
- ID: 227
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About the authors
M. A. Lobov
Moscow Regional Scientific Research and Clinical Institute
Email: lobovma@mail.ru
Russian Federation, Moscow
A. A. Dreval
Russian Scientific Research Medical University
Email: lobovma@mail.ru
Russian Federation, Moscow
A. M. Ovezov
Moscow Regional Scientific Research and Clinical Institute
Email: lobovma@mail.ru
Russian Federation, Moscow
M. V. Panteleeva
Moscow Regional Scientific Research and Clinical Institute
Email: lobovma@mail.ru
Russian Federation, Moscow
N. R. Pashina
Russian Scientific Research Medical University
Email: lobovma@mail.ru
Russian Federation, Moscow
A. V. Knyazev
Moscow Regional Scientific Research and Clinical Institute
Email: lobovma@mail.ru
Russian Federation, Moscow
M. N. Borisova
Moscow Regional Scientific Research and Clinical Institute
Email: lobovma@mail.ru
Russian Federation, Moscow
A. V. Lugovoy
Moscow Regional Scientific Research and Clinical Institute
Author for correspondence.
Email: lobovma@mail.ru
Russian Federation, Moscow
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).