Influence of propofol on hippocampus in developing brain: an experimental study

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Abstract

Anesthetic neurotoxicity and intraoperative cerebral neuroprotectioan is one of the important issues in modern anesthesiology. General anesthesia, in addition to its hypnotic effect, is considered to cause postoperative cognitive dysfunction as a manifestation of encephalopathy. Narcosis based on propofol is a “gold standard” of total intravenous anesthesia and is frequently used for surgery in patients of various ages. This experimental study investigates the effects of propofol on neuronal population in hippocampus of immature rats. In propofol-anesthezied rats within 30 min of exposition, a two-fold increase of altered hippocampal neurons was detected compared to control animals, however no neuronal cell death was observed. Intraoperative use of ethylmethylhydroxypyridine succinate ameliorates propofol-induced neuronal damagethat proves a neuroprotective effect of the drug tested.

 
 

About the authors

M. A. Lobov

Moscow Regional Scientific Research and Clinical Institute

Email: lobovma@mail.ru
Россия, Moscow

A. A. Dreval

Russian Scientific Research Medical University

Email: lobovma@mail.ru
Россия, Moscow

A. M. Ovezov

Moscow Regional Scientific Research and Clinical Institute

Email: lobovma@mail.ru
Россия, Moscow

M. V. Panteleeva

Moscow Regional Scientific Research and Clinical Institute

Email: lobovma@mail.ru
Россия, Moscow

N. R. Pashina

Russian Scientific Research Medical University

Email: lobovma@mail.ru
Россия, Moscow

A. V. Knyazev

Moscow Regional Scientific Research and Clinical Institute

Email: lobovma@mail.ru
Россия, Moscow

M. N. Borisova

Moscow Regional Scientific Research and Clinical Institute

Email: lobovma@mail.ru
Россия, Moscow

A. V. Lugovoy

Moscow Regional Scientific Research and Clinical Institute

Author for correspondence.
Email: lobovma@mail.ru
Россия, Moscow

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Copyright (c) 2013 Lobov M.A., Dreval A.A., Ovezov A.M., Panteleeva M.V., Pashina N.R., Knyazev A.V., Borisova M.N., Lugovoy A.V.

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