Current means for identifying the latent stage of a neurodegenerative process

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Abstract

A characteristic feature of neurodegenerative diseases is the presence of a long-term latent stage, while manifestation of symptoms occurs after 40–60% cells loss in vulnerable neuron populations. Therefore, potential for neuroprotection is maximal just at the latent stage of the process. In this paper, current technologies of presymptomatic diagnosis of the two most common neurodegenerative disorders, Alzheimer’s and Parkinson’s
disease, are presented. On the basis of our own experience and data from the literature it is shown that neuroimaging methods (identification of beta-amyloid in the brain, or phenomenon of hyperechogenecity of the s.nigra, etc) in combination with a number of neurophysiological and molecular/pathobiochemical tests are principal in revealing persons with high risk of these disorders. Validation of biomarkers under discussion and their integration
into uniform diagnostic screening algorithms is at present one of the most actual fields of neurology.

About the authors

Sergey N. Illarioshkin

Research Center of Neurology

Author for correspondence.
Email: snillario@gmail.com
Russian Federation, Moscow

A. G. Vlassenko

Department of Radiology, Washington University School of Medicine

Email: snillario@gmail.com
United States, St. Louis

Ekaterina Yu. Fedotova

Research Center of Neurology

Email: snillario@gmail.com
ORCID iD: 0000-0001-8070-7644

D. Sci. (Med.), Head of the 5th Neurology department

Russian Federation, Moscow

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