Current means for identifying the latent stage of a neurodegenerative process
- Authors: Illarioshkin S.N.1, Vlassenko A.G.2, Fedotova E.Y.1
-
Affiliations:
- Research Center of Neurology
- Department of Radiology, Washington University School of Medicine
- Issue: Vol 7, No 2 (2013)
- Pages: 39-50
- Section: Technologies
- Submitted: 02.02.2017
- Published: 09.02.2017
- URL: https://annaly-nevrologii.com/journal/pathID/article/view/236
- DOI: https://doi.org/10.17816/psaic236
- ID: 236
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Full Text
Abstract
A characteristic feature of neurodegenerative diseases is the presence of a long-term latent stage, while manifestation of symptoms occurs after 40–60% cells loss in vulnerable neuron populations. Therefore, potential for neuroprotection is maximal just at the latent stage of the process. In this paper, current technologies of presymptomatic diagnosis of the two most common neurodegenerative disorders, Alzheimer’s and Parkinson’s
disease, are presented. On the basis of our own experience and data from the literature it is shown that neuroimaging methods (identification of beta-amyloid in the brain, or phenomenon of hyperechogenecity of the s.nigra, etc) in combination with a number of neurophysiological and molecular/pathobiochemical tests are principal in revealing persons with high risk of these disorders. Validation of biomarkers under discussion and their integration
into uniform diagnostic screening algorithms is at present one of the most actual fields of neurology.
About the authors
Sergey N. Illarioshkin
Research Center of Neurology
Author for correspondence.
Email: snillario@gmail.com
Russian Federation, Moscow
A. G. Vlassenko
Department of Radiology, Washington University School of Medicine
Email: snillario@gmail.com
United States, St. Louis
Ekaterina Yu. Fedotova
Research Center of Neurology
Email: snillario@gmail.com
ORCID iD: 0000-0001-8070-7644
D. Sci. (Med.), Head of the 5th Neurology department
Russian Federation, MoscowReferences
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