Neurospecific peptides in the assessment of brain damage in patients with atherothrombotic stroke

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Abstract

Assessment of neurospecific peptides provide quantitative information about the severity of ischemic cell damage. We studied 26 patients with atherothrombotic stroke. Control group comprised 15 healthy volunteers. Each patient underwent neurological examination and CT or MRI of the brain on admission. Patients with documented or clinical evidence of nervous system tumor, brain infarction, hemorrhage, head trauma, or central nervous system infection within 3 months before admission were excluded from this study. Stroke severity was rated using the National Institutes of Health Stroke Scale. S100 and NSE assays were performed using a radioimmunoassay technique. S100 and NSE levels were measured in cerebrospinal fluid (CSF) and serum. CSF and serum S100 and NSE levels were elevated in patients with atherothrombotic stroke compared with the control group. Elevation of S100 and NSE levels in CSF and serum after ischemic stroke may be a result of combined leakage out of necrotic cells and passage through an impaired brain-blood barrier, indicating severe ischemic cell injury.

 

About the authors

Marina Yu. Maximova

Research Center of Neurology

Email: ncnmaximova@mail.ru
ORCID iD: 0000-0002-7682-6672

D. Sci (Med,), Professor, Head, 2nd Neurology department, Research Center of Neurology

Russian Federation, Moscow

V. G. Ionova

Research Center of Neurology

Email: ncnmaximova@mail.ru
Russian Federation, Moscow

E. N. Syskina

Moscow State Medical-Stomatologic University

Email: ncnmaximova@mail.ru
Russian Federation, Moscow

Аlla A. Shabalina

Research Center of Neurology

Email: ncnmaximova@mail.ru
ORCID iD: 0000-0001-9604-7775

D. Sci. (Med.), leading researcher, Head, Laboratory of hemorheology, hemostasis and pharmacokinetics (with clinical laboratory diagnostics)

Russian Federation, Moscow

Marina V. Kostyreva

Research Center of Neurology

Email: ncnmaximova@mail.ru
Russian Federation, Moscow

O. A. Sinektutova

Moscow State Medical-Stomatologic University

Author for correspondence.
Email: ncnmaximova@mail.ru
Russian Federation, Moscow

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Copyright (c) 2011 Maximova M.Y., Ionova V.G., Syskina E.N., Shabalina A.A., Kostyreva M.V., Sinektutova O.A.

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