Роль генетических факторов в формировании индивидуальной предрасположенности к ишемическому инсульту

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Интенсивное развитие технологий анализа ДНК и масштабные исследования полногеномных ассоциаций привели к накоплению большого массива данных о связи генетических факторов с различными фенотипическими проявлениями, в т.ч. с моногенными и полигенными наследственными заболеваниями. Благодаря этому значительно расширились возможности клинической диагностики и предиктивной медицины в области социально значимых заболеваний. Так, в настоящее время активно развиваются исследования генетического компонента в формировании риска развития такого многофакторного и полиэтиологического заболевания, как инсульт. В крупномасштабных исследованиях выявлены как общие, так и специфические генетические маркеры, ассоциированные только с инсультом определенного типа и подтипа. В настоящем обзоре проведен анализ современного состояния проблемы использования генетических маркеров для диагностики предрасположенности к инсульту, сложных вопросов, связанных с множественностью факторов риска инсульта, а также возможных путей развития данного направления.

Об авторах

Виталий Иванович Корчагин

ФБУН «Центральный НИИ эпидемиологии» Роспотребнадзора

Email: vitaly_korchagin@rambler.ru
Россия, Москва

K. O. Миронов

ФБУН «Центральный НИИ эпидемиологии» Роспотребнадзора

Email: vitaly_korchagin@rambler.ru
Россия, Москва

O. П. Дрибноходова

ФБУН «Центральный НИИ эпидемиологии» Роспотребнадзора

Email: vitaly_korchagin@rambler.ru
Россия, Москва

Марина Юрьевна Максимова

ФГБНУ «Научный центр неврологии»

Email: vitaly_korchagin@rambler.ru
ORCID iD: 0000-0002-7682-6672
Россия, Москва, Волоколамское шоссе, 80

Сергей Николаевич Иллариошкин

ФГБНУ «Научный центр неврологии»

Email: vitaly_korchagin@rambler.ru
ORCID iD: 0000-0002-2704-6282

д.м.н., проф., член-корр. РАН, зам. директора по научной работе, рук. отдела исследований мозга

Россия, Москва

Маринэ Мовсесовна Танашян

ФГБНУ «Научный центр неврологии»

Email: vitaly_korchagin@rambler.ru
ORCID iD: 0000-0002-5883-8119

д.м.н., профессор, член-корреспондент РАН, зам. директора по научной работе, рук. 1-го неврологического отделения

Россия, Москва

A. И. Платонов

ФБУН «Центральный НИИ эпидемиологии» Роспотребнадзора

Email: vitaly_korchagin@rambler.ru
Россия, Москва

Г. A. Шипулин

ФБУН «Центральный НИИ эпидемиологии» Роспотребнадзора

Email: vitaly_korchagin@rambler.ru
Россия, Москва

Антон Алексеевич Раскуражев

ФГБНУ «Научный центр неврологии»

Email: vitaly_korchagin@rambler.ru
ORCID iD: 0000-0003-0522-767X

к.м.н., врач-невролог, с.н.с. 1-го неврологического отделения

Россия, Москва

Михаил Александрович Пирадов

ФГБНУ «Научный центр неврологии»

Автор, ответственный за переписку.
Email: vitaly_korchagin@rambler.ru
ORCID iD: 0000-0002-6338-0392

д.м.н., проф., академик РАН, директор

Россия, Москва

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