A role of genetic factors in the development of individual predisposition to ischemic stroke

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Abstract

Intensive development of DNA analysis technologies and largescale genome-wide association studies have led to accumulation of a large array of data on the relationship between genetic factors and various phenotypic manifestations, including monogenic and polygenic hereditary diseases. This greatly has extended the capabilities of clinical diagnostics and predictive medicine in the field of socially significant diseases. For example, a role of a genetic component of the risk for such a multifactorial and polyetiologic disease as stroke is now actively explored. Large-scale studies have revealed both general and specific genetic markers associated only with a certain type and subtype of stroke. This review analyzes the current state of the problem of using genetic markers for diagnosis of stroke predisposition, complex issues associated with multiplicity of risk factors for stroke, and possible development in this area.

About the authors

V. I. Korchagin

Central Research Institute of Epidemiology

Email: vitaly_korchagin@rambler.ru
Россия, Moscow

K. O. Mironov

Central Research Institute of Epidemiology

Email: vitaly_korchagin@rambler.ru
Россия, Moscow

O. P. Dribnokhodova

Central Research Institute of Epidemiology

Email: vitaly_korchagin@rambler.ru
Россия, Moscow

Marina Yu. Maksimova

Research Center of Neurology, Moscow

Email: vitaly_korchagin@rambler.ru
ORCID iD: 0000-0002-7682-6672
Россия, Moscow, Volokolamskoe shosse,80

Sergey N. Illarioshkin

Research Center of Neurology

Email: vitaly_korchagin@rambler.ru
ORCID iD: 0000-0002-2704-6282

D. Sci. (Med.), Prof., Corr. Member of the Russian Academy of Sciences, Deputy Director, Head, Department for brain research

Россия, Moscow

Marine M. Tanashyan

Research Center of Neurology

Email: vitaly_korchagin@rambler.ru
ORCID iD: 0000-0002-5883-8119

D. Sci. (Med.), Prof., Corresponding member of RAS, Deputy Director for science, Head, 1st Neurological department

Россия, Moscow

A. E. Platonov

Central Research Institute of Epidemiology

Email: vitaly_korchagin@rambler.ru
Россия, Moscow

G. A. Shipulin

Central Research Institute of Epidemiology

Email: vitaly_korchagin@rambler.ru
Россия, Moscow

Anton A. Raskurazhev

Research Center of Neurology

Email: vitaly_korchagin@rambler.ru
ORCID iD: 0000-0003-0522-767X

Cand. Sci. (Med.), neurologist, researcher, 1st Neurology department

Россия, Moscow

Mikhail A. Piradov

Research Center of Neurology

Author for correspondence.
Email: vitaly_korchagin@rambler.ru
ORCID iD: 0000-0002-6338-0392

D. Sci. (Med.), Professor, Full Member of the Russian Academy of Sciences, Director

Россия, Moscow

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Copyright (c) 2016 Korchagin V.I., Mironov K.O., Dribnokhodova O.P., Maxsimova M.Y., Illarioshkin S.N., Tanashyn M.M., Platonov A.E., Shipulin G.A., Raskurazhev A.A., Piradov M.A.

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