Capabilities of contrast-enhanced ultrasound in angioneurology

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Abstract

Contrast-enhanced ultrasound is a new promising direction in angio imaging, which has been increasingly used in clinical practice in recent years. We describe the history of the development of this method and consider in detail the basic physical and technical principles of contrast-enhanced ultrasound as well as modern capabilities of its use in diagnosis of various vascular diseases of the brain.

About the authors

Andrey O. Chechetkin

Research Center of Neurology

Email: andreychechetkin@gmail.com
ORCID iD: 0000-0002-8726-8928

D. Sci. (Med.), Head, Ultrasound diagnostic laboratory

Россия, Moscow

L. D. Druina

Research Center of Neurology

Author for correspondence.
Email: andreychechetkin@gmail.com
Россия, Moscow

References

  1. Бокерия Л.А., Покровский А.В., Сокуренко Г.Ю. и др. Национальные рекомендации по ведению пациентов с заболеваниями брахиоцефальных артерий. Российский согласительный документ. Ангиология и сосудистая хирургия. 2013; 2 (Приложение 19): 1–70.
  2. Гулевская Т.С., Моргунов В.А., Ануфриев П.Л. и др. Морфологическая структура атеросклеротических бляшек синуса внутренней сонной артерии и их ультразвуковая характеристика. Ультразвуковая и функциональная диагностика 2004; 4: 68–77.
  3. Новиков Н.Е. Контрастно-усиленные ультразвуковые исследования. История развития и современные возможности. Russian Electr. J. Radiol. 2012; 2 (1): 20–28.
  4. Осипов Л.В. Ультразвуковые диагностические приборы. Режимы, методы, технологии. М.: Изомед, 2001.
  5. Покровский А.В., Зотиков А.Е., Юдин В.И. Неспецифический аортоартериит (болезнь Такаясу). М: ИРИСЪ, 2002.
  6. Фомина С.В., Завадовская В.Д., Юсубов М.С. и др. Контрастные препараты для ультразвукового исследования. Бюл. сибирской мед. 2011; 6: 137–142.
  7. Alonso A., Artemis D., Hennerici M. Molecular imaging of carotid plaque vulnerability. Cerebrovasc Dis. 2015. 39: 5–12.
  8. Bolognese M., Artemis D., Alonso A. et al. Relationship between refillkinetics of ultrasound perfusion imaging and vascular obstruction in acute middle cerebral artery stroke. In: E. Bartels, Bartels S., Poppert H. (eds.) New Trends in Neurosonology and Cerebral Hemodynamics -an Update. Perspectives in Medicine 2012: 39–43.
  9. Brott T.G., Halperin J.L., Abbara S. et al. Guideline on the management of patients with extracranial carotid and vertebral artery disease. J.Am. Coll. Cardiol. 2011. 57: e16–94.
  10. Coli S., Magnoni M., Sangiorgi G. et al. Contrast-enhanced ultrasound imaging of intraplaque neovascularization in carotid arteries: correlation with histology and plaque echogenicity. J. Am. Coll. Cardiol. 2008. 52: 223–230.
  11. Culp W., Flores R., Brown A. et al. Successful microbubble sonothrombolysis without tissue-type plasminogen activator in a rabbit model of acute ischemic stroke. Stroke 2011; 42: 2280–2285.
  12. Eliasziw M., Fox A., Hachinski V. et al. Significance of plaque ulceration in symptomatic patients with high-grade carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial. Stroke 1994; 25:304–308.
  13. Federlein J., Postert T., Meves S. et al. Ultrasonic evaluation of pathological brain perfusion in acute stroke using second harmonic imaging. J. Neurol. Neurosurg. Psychiatry 2000; 69: 616–622.
  14. Feinstein S. Contrast ultrasound imaging of the carotid artery vasa vasorum and atherosclerotic plaque neovascularization. J. Am. Coll. Cardiol. 2006; 48: 236–243.
  15. Fisher M., Paganini-Hill A., Martin A. et al. Carotid plaque pathology: thrombosis, ulceration, and stroke pathogenesis. Stroke 2005; 36:253–257.
  16. Flores R., Hennings L., Lowery J. et al. Microbubble-augmented ultrasound sonothrombolysis decreases intracranial hemorrhage in a rabbit model of acute ischemic stroke. Invest. Radiol. 2011; 46: 419–424.
  17. Giannoni M., Vicenzini E., Citone M. et al. Contrast carotid ultrasound for the detection of unstable plaques with neoangiogenesis: a pilot study. Eur. J. Vasc. Endovasc. Surg. 2009; 37: 722–727.
  18. Giordana P., Baque-Juston M., Jeandel P. et al. Contrast-enhanced ultrasound of carotid artery wall in Takayasu disease: first evidence of application in diagnosis and monitoring of response to treatment. Circulation 2011; 124: 245–247.
  19. Gramiak R., Shah P. Echocardiography of the aortic root. Invest. Radiol. 1968; 3: 356–366.
  20. Gronholdt M., Nordestgaard B., Schroeder T. et al. Ultrasonic echolucent carotid plaques predict future strokes. Circulation 2001; 104: 68–73.
  21. Hoogi A., Adam D., Hoffman A. et al. Carotid plaque vulnerability: quantification of neovascularization on contrast-enhanced ultrasound with histopathologic correlation. Am. J. Roentgenol. 2011; 196: 431–436.
  22. Huang P., Huang F., Zou C. et al. Contrast-enhanced sonographic characteristics of neovascularization in carotid atherosclerotic plaques. J. Clin. Ultrasound 2008; 36: 346–351.
  23. Kaspar M., Partovi S., Aschwanden M. et al. Assessment of microcirculation by contrast-enhanced ultrasound: a new approach in vascular medicine. Swiss Med. Wkly 2015; 145: w14047.
  24. Kern R., Diels A., Pettenpohl J. et al. Real-time ultrasound brain perfusion imaging with analysis of microbubble replenishment in acute MCA stroke. J. Cereb. Blood Flow Metab. 2011; 31: 1716–1724.
  25. Magnoni M., Dagna L., Coli S. et al. Assessment of Takayasu arteritis activity by carotid contrast-enhanced ultrasound. Circ. Cardiovasc. Imaging 2011; 4: e1–e2.
  26. McCarthy M., Loftus I., Thompson M. et al. Angiogenesis and the atherosclerotic carotid plaque: an association between symptomatology and plaque morphology. J. Vasc. Surg. 1999; 30: 261–268.
  27. Meairs S. Advances in neurosonology — Brain perfusion, sonothrombolysis and CNS drug delivery. In: E. Bartels, Bartels S., Poppert H. (eds.) New Trends in Neurosonology and Cerebral Hemodynamics — an Update. Perspectives in Medicine 2012: 5–10.
  28. Meyer K., Wiesmann M., Albers T., Seidel G. Harmonic imaging in acute stroke: detection of a cerebral perfusion deficit with ultrasound and perfusion MRI. J. Neuroimaging 2003; 13: 166–168.
  29. Mono M.L., Karameshev A., Slotboom J. et al. Plaque characteristics of asymptomatic carotid stenosis and risk of stroke. Cerebrovasc. Dis. 2012; 34: 343–350.
  30. Piscaglia F., Nolsoe C., Dietrich C. et al. The EFSUMB Guidelines and Recommendations on the Clinical Practice of Contrast Enhanced Ultrasound (CEUS): update 2011 on non-hepatic applications. Ultraschall Med. 2012; 33: 33–59.
  31. Ries S., Steinke W., Neff K., Hennerici M. Echocontrast-enhanced transcranial color-coded sonography for the diagnosis of transverse sinus venous thrombosis. Stroke 1997; 28: 696–700.
  32. Rothwell P., Gibson R., Warlow C. Interrelation between plaque surface morphology and degree of stenosis on carotid angiograms and the risk of ischemic stroke in patients with symptomatic carotid stenosis. On behalf of the European Carotid Surgery Trialists’ Collaborative Group. Stroke 2000; 31: 615–621.
  33. Saba L., Caddeo G., Sanfilippo R. et al. CT and ultrasound in the study of ulcerated carotid plaque compared with surgical results: potentialities and advantages of multidetector row CT angiography. Am. J. Neuroradiol. 2007; 28: 1061–1066.
  34. Schinkel A., van den Oord S., van der Steen A. et al. Utility of contrast-enhanced ultrasound for the assessment of the carotid artery wall in patients with Takayasu or giant cell arteritis. Eur. Heart J. Cardiovasc. Imaging 2014; 15: 541–546.
  35. Seidel G., Meyer-Wiethe K., Berdien G. et al. Ultrasound perfusion imaging in acute middle cerebral artery infarction predicts outcome. Stroke 2004; 35: 1107–1111.
  36. Shah F., Balan P., Weinberg M. et al. Contrast-enhanced ultrasound imaging of atherosclerotic carotid plaque neovascularization: a new surrogate marker of atherosclerosis? Vasc. Med. 2007; 12: 291–297.
  37. Staub D., Partovi S., Schinkel A. et al. Correlation of carotid artery atherosclerotic lesion echogenicity and severity at standard US with intraplaque neovascularization detected at contrast-enhanced US. Radiology 2011; 258: 618-626.
  38. Staub D., Partovi S., Imfeld S. et al. Novel applications of contrastenhanced ultrasound imaging in vascular medicine. Vasa 2013; 42: 17-31.
  39. Staub D., Patel M.B., Tibrewala A. et al. Vasa vasorum and plaque neovascularization on contrast-enhanced carotid ultrasound imaging correlates with cardiovascular disease and past cardiovascular events. Stroke 2010; 41: 41–47.
  40. Ten Kate G., van Dijk A., van den Oord S. et al. Usefulness of contrast-enhanced ultrasound for detection of carotid plaque ulceration in patients with symptomatic carotid atherosclerosis. Am. J. Cardiol. 2013; 112: 292–298.
  41. Topakian R., King A., Kwon S. et al. Ultrasonic plaque echolucency and emboli signals predict stroke in asymptomatic carotid stenosis. Neurology 2011; 77: 751–758.
  42. Vicenzini E., Giannoni M., Puccinelli F. et al. Detection of carotid adventitial vasa vasorum and plaque vascularization with ultrasound cadence contrast pulse sequencing technique and echo-contrast agent. Stroke 2007; 38: 2841–2843.
  43. Xiong L., Deng Y., Zhu Y. et al. Correlation of carotid plaque neovascularization detected by using contrast-enhanced US with clinical symptoms. Radiology 2009; 251: 583–589.

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Copyright (c) 2015 Chechetkin A.O., Druina L.D.

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