Neuroprotection in cerebrovascular diseases: is it the search for life on Mars or a promising trend of treatment? Part 1. Acute stroke

Abstract

The two key strategies of specific treatment of stroke are reperfusion, aimed on the improvement of brain perfusion in the ischemic region due to the restoration of blood flow and prevention of recurrent thrombosis, and neuroprotection to maintain brain tissue metabolism and to protect it from structural damage. The evidential base of major neuroprotective drugs (nimodipine, magnesium sulfate, piracetam, ethylmethylhydroxypyridine succinate, choline alfoscerate, cerebrolysin, albumin, citicoline, edaravone) and hypothermia use in acute stroke setting is critically reviewed in the article.

 

About the authors

M. A. Piradov

Research Center of Neurology (Moscow)

Author for correspondence.
Email: platonova@neurology.ru
Russian Federation

M. M. Tanashyan

Research Center of Neurology (Moscow)

Email: platonova@neurology.ru
Russian Federation

M. A. Domashenko

Research Center of Neurology (Moscow)

Email: platonova@neurology.ru
Russian Federation

D. V. Sergeev

Research Center of Neurology (Moscow)

Email: platonova@neurology.ru
Russian Federation

M. Yu. Maksimova

Research Center of Neurology (Moscow)

Email: platonova@neurology.ru
Russian Federation

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