Neurological complications in acute leukemia in children

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Abstract

The success of treatment of acute leukemia in children is determined by the biological type of the disdorder, the volume of the tumor mass, extramedullary manifestations and toxic complications resulting from chemotherapy. Analysis of risk factors, clinical data and neuroimaging may help to clarify the cause of the pathology of the central nervous system and to select the optimal method of treatment.

About the authors

L. M. Shchugareva

North-West State Medical University named after I.I. Mechnikov; Municipal Hospital for Children № 1

Author for correspondence.
Email: platonova@neurology.ru
Russian Federation

A. S. Iova

North-West State Medical University named after I.I. Mechnikov

Email: platonova@neurology.ru
Russian Federation

O. V. Ivanova

Municipal Hospital for Children № 1

Email: platonova@neurology.ru
Russian Federation

E. G. Boychenko

Municipal Hospital for Children № 1

Email: platonova@neurology.ru
Russian Federation

I. A. Garbuzova

Municipal Hospital for Children № 1

Email: platonova@neurology.ru
Russian Federation

N. V. Stancheva

Institute of Pediatric Hematology and Transplantology named after R.M. Gorbacheva, Saint-Petersburg State Medical University named after I.P. Pavlov (Saint-Petersburg)

Email: platonova@neurology.ru
Russian Federation

S. N. Bondarenko

Institute of Pediatric Hematology and Transplantology named after R.M. Gorbacheva, Saint-Petersburg State Medical University named after I.P. Pavlov (Saint-Petersburg)

Email: platonova@neurology.ru
Russian Federation

T. A. Khutornaya

Institute of Pediatric Hematology and Transplantology named after R.M. Gorbacheva, Saint-Petersburg State Medical University named after I.P. Pavlov (Saint-Petersburg)

Email: platonova@neurology.ru
Russian Federation

L. S. Zubarovskaya

Institute of Pediatric Hematology and Transplantology named after R.M. Gorbacheva, Saint-Petersburg State Medical University named after I.P. Pavlov (Saint-Petersburg)

Email: platonova@neurology.ru
Russian Federation

References

  1. Вильчевская Е.В. Поздние осложнения профилактики нейролейкемии для нервной системы детей с острым лимфобластным лейкозом. Укр. журн. гематол. Трансфузiол. 2002; 4: 25–29.
  2. Зильбер Л.А. Об изучении этиологии и иммунологии опухолей. Вопр. онкол. 2005; 2: 148–153.
  3. Чучин М.Ю., Ушакова Л.В. Тромбоз церебральных синусов отогенной природы в практике детского невролога. Педиатрия 2009; 6: 55–60.
  4. Byrd J.C., Edenfield W.J., Shields D.J. et al. Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review. J Clin Oncol 1995; 13: 1800–1816.
  5. Caruso V., Iacoviello L., Di Castelnuovo A. et al. Thrombotic complications in childhood acute lymphoblastic leukemia: a metaanalysis of 17 prospective studies comprising 1752 pediatric patients.Blood 2006; 108: 2216–2222.
  6. Castelli R., Ferrari B., Cortelezzi A. Thromboembolic complications in malignant haematological disorders. Curr. Vasc. Pharmacol. 2010; 8: 482–494.
  7. Chamberlain M.C. Leukemia and the nervous system. Medicine Current Oncology Reports. Cancer Neurology in Clinical Practice. 2008. Part VII: 555–565.
  8. Chamberlain M.C. Neoplastic meningitis. Oncologist 2008; 9: 967–977.
  9. Ficek K., Blamek S., Syguła D. et al. Evaluation of the late effects of CNS prophylactic treatment in childhood acute lymphoblastic leukemia (ALL) using magnetic resonance spectroscopy. Acta Neurochir. Suppl. 2010; 106: 195–197.
  10. Hernández B., Dronda F., Moreno S. Treatment options for AIDS patients with progressive multifocal leukoencephalopathy. Expert Opin. Pharmacother. 2009; 3: 403–416.
  11. Hopkins T.J., Raducan V., Sioutos N. Lumbar lymphoma presenting as psoas abscess/epidural mass with acute cauda equina syndrome. A case report. Spine 1993; 18: 774–778.
  12. Horowitz N., Brenner B. Thrombophilia and cancer. Pathophysiol. Haemost. Thromb. 2008; 3-4: 131–136.
  13. Ishimori M.L., Pressman B.D., Wallace D.J., Weisman M.H. Posterior reversible encephalopathy syndrome: another manifestation of CNS SLE? Lupus 2007; 16: 436–443.
  14. Kobayashi Y., Takahashi S., Mizuno T. et al. Acute promyelocytic leukemia with CNS leukemia – a report of two cases. Gan. No Rinsh. 1988; 34: 1153–1158.
  15. Küker W., Bader P., Herrlinger U. Transient encephalopathy after intrathekal methotrexate chemotherapy: diffusion-weighted MRI. J. Neuro-Oncology 2005; 73: 47–49.
  16. Kun L.E. Leukemias in children. Pediatr. Rad. Oncol. 2007; 7: 15–39.
  17. Kuroda Y., Kosugi M. Clinical characteristics, diagnostic criteria and treatment of progressive multifocal leukoencephalopathy. Nippon Rinsho 2007; 8: 1501–1505.
  18. Laningham F.H., Kun L.E., Wilburn R.E. et al. Childhood central nervous system leukemia: historical perspectives, current therapy, and acute neurological sequelae. Neuroradiology 2007; 49: 873–888.
  19. Laningham F.H., Kun L.E., Wilburn R.E. et al. Childhood central nervous system leukemia: historical perspectives, current therapy, and acute neurological sequelae. Neuroradiology 2007; 11: 873–888.
  20. Mandrell B.N. The genetic profile and monitoring of acute lymphoblastic leukemia in children and adolescents. J. Pediatr. Nurs. 2009; 24: 173–178.
  21. Mennes M., Stiers P., Vandenbussche E. Attention and information processing in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only. Pediatr. Blood Cancer 2005; 44: 478–486.
  22. Morris E.B. Laningham F.H., Sandlund J.T., Khan R.B. Posterior reversible encephalopathy syndrome in children with cancer. Pediatr. Blood Cancer 2007; 48: 152–159.
  23. Newton H.B., Jolesz F.A. Handbook of neuro-oncology neuroimaging. Elsevier Science & Technology Books, 2007.
  24. Peterson B.A., Brunning R.D., Bloomfield C.D. et al. CNS involvement in acute nonlymphocytic leukemia: a prospective study of adults in remission. Am. J. Med. 1987; 83: 464–470.
  25. Phipps S., Rai S.N., Leung W.H. et al. Cognitive and academic consequences of stem-cell transplantation in children. J. Clin. Oncol. 2008; 20/26 (12): 2027–2033.
  26. Piatkowska-Jakubas B., Krawczyk-Kuliś M., Giebel S. et al. Use of
  27. L-asparaginase in acute lymphoblastic leukemia: recommendations of the Polish Adult Leukemia Group. Pol. Arch. Med. Wewn. 2008; 118: 664–669.
  28. Porto L. Kieslich M., Schwabe D. Central nervous system imaging in childhood leukaemia. Eur. J. Cancer 2004; 40: 2082–2090.
  29. Priest J.R., Ramsay N.K., Latchaw R.E. Thrombotic and hemorrhagic strokes complicating early therapy for childhood acute lymphoblastic leukemia. Cancer J. Clinicians 2006; 7: 1548–1554.
  30. Priest J.R., Ramsay N.K., Latchaw R.E. Thrombotic and hemorrhagic strokes complicating early therapy for childhood acute lymphoblastic leukemia. Cancer J. Clinicians. 2006; 7: 1548–1554.
  31. Pui C.H., Campana D., Pei D. et al. Treating childhood acute lymphoblastic leukemia without cranial irradiation. N. Engl. J. Med. 2009; 360: 2730–2741.
  32. Pui C.H., Evans W.E. Treatment of acute lymphoblastic leukemia. N. Engl. J. Med. 2006; 354: 166–178.
  33. Ravandi F., Cortes J., Estrov Z. et al. CD56 expression predicts occurrence of CNS disease in acute lymphoblastic leukemia. Leuk. Res. 2002; 26: 643–649.
  34. Reddick W.E., Laningham F.H., Glass J.O. et al. Quantitative morphologic evaluation of magnetic resonance imaging during and after treatment of childhood leukemia. Neuroradiology 2007; 49: 889–904.
  35. Sagduyu A., Sirin H., Mulayim S. et al. Cerebral cortical and deep venous thrombosis without sinus thrombosis: clinical MRI correlates. Acta Neurol. Scand. 2006; 114: 254–260.
  36. Sandovala C., Kutschera M., Jayabosea S., Tennerb М. Neurotoxicity of intrathecal methotrexate: MR imaging findings. Аm. J. Neuroradiol. 2003; 24: 1887-1890.
  37. Santoro N., Giordano P., Del Vecchio G.C. et al. Ischemic stroke in children treated for acute lymphoblastic leukemia: a retrospective study. J. Pediatr. Hematol. Oncol. 2005; 27: 153-157.
  38. Schmiegelow K., Vestergaard T., Nielsen S. M., Hjalgrim H. Etiology of common childhood acute lymphoblastic leukemia: the adrenal hypothesis. Leukemia 2008; 22: 2137-2141.
  39. Shah R., Bag A.K., Chapman P. R., Curé J.K. Imaging manifestations of progressive multifocal leukoencephalopathy. Clin. Radiol. 2010; 65:431-439.
  40. Skoczeń S., Balwierz W., Kroczka S. Late neurological complications after termination of treatment of acute lymphoblastic leukemia in children. Przegl. Lek. 2004; 61 (Suppl. 2): 76-80.
  41. Skoczeń S., Balwierz W., Kroczka S. et al. Late neurological complications after termination of treatment of acute lymphoblastic leukemia in children. Lek. 2004; 61 (Suppl. 2): 76-80.
  42. Skórzewska A., Bidziński A. Changes in hippocampal amino acid concentrations after chronic administration of corticosterone. Pharmacol. Rep. 2007; 59: 763-772.
  43. Stanulla M., Schaffeler E., Arens S. et al. GSTP1 and MDR1 genotypes and central nervous system relapse in childhood acute lymphoblastic leukemia. Int. J. Hematol. 2005; 81: 39-44.
  44. Steffen-Smith E.A., Wolters P.L., Albert P.S. et al. Detection and characterization of neurotoxicity in cancer patients using proton MR spectroscopy. Childs Nerv. Syst. 2008; 24: 807-813.
  45. Surapaneni U.R., Cortes J.E., Thomas D. et al. Central nervous system relapse in adults with acute lymphoblastic leukemia. The best summary of outcome in adult patients with leukemic meningitis treated at a single institution. Cancer 2002; Apr. 16(4): 773-780.
  46. Taub J.W., Ge Y. The prenatal origin of childhood acute lymphoblastic leukemia Lymphoma 2004; 45: 19-25.
  47. Ulu E.M., Töre H.G., Bayrak A. et al. MRI of central nervous system abnormalities in childhood leukemia. Diagn. Interv. Radiol. 2009; 15: 86-92.
  48. Unal S., Varan A., Yalсin B. Evaluation of thrombotic children with malignancy. Ann. Hematol. 2005; 84: 395-399.
  49. von der Weid N.X. Adult life after surviving lymphoma in childhood. Support Care Cancer 2008; Apr. 16(4): 339-345.
  50. Won S.C., Han J.W., Choi S.Y., Lyu C.J. Posterior reversible encephalopathy syndrome in childhood with hematologic/oncologic diseases. J. Pediatr. Hematol. Oncol. 2009; 31: 505-508.
  51. Wong C.S., A. J. Van der Kogel. Mechanisms of radiation injury to the central nervous system: implications for neuroprotection. Mol. Interv. 2004; 4: 273-284.
  52. Yeoh E.J., Ross E., Shurtleff S.A. et al. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 2002; 1: 133-143.
  53. Zuccoli G., Pipitone N., De Carli N., et al. Acute spinal cord compression due to epidural lipomatosis complicated by an abscess: magnetic resonance and pathology findings. Eur. Spine J. 2010; 19 (Suppl.2): 216-219.

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Copyright (c) 2014 Shchugareva L.M., Iova A.S., Ivanova O.V., Boychenko E.G., Garbuzova I.A., Stancheva N.V., Bondarenko S.N., Khutornaya T.A., Zubarovskaya L.S.

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