Modern pharmacological models of Alzheimer’s disease

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Abstract

In vivo experimental models of Alzheimer’s disease are powerful tools for studying the mechanisms of pathogenesis and the search for new therapeutic agents. Pharmacological models, based on the injection of neurotoxins (beta-amyloid fragments, cholinotoxins, ibotenic acid) into the brain allow simulation the cognitive impairment typical for Alzheimer’s disease, and yield evaluation the impact of drugs on various indicators (biochemical, genetic, electrophysiological). The most validity was showed for the in vivo model of neurotoxic beta-amyloid fragments injection into basal forebrain nuclei.

About the authors

V. V. Kolobov

Research Center of Neurology Russian Academy of Medical Sciences

Email: f.neurochemistry@gmail.com
Russian Federation, Moscow

Z. I. Storozheva

Serbsky National Research Centre for Social and Forensic Psychiatry

Author for correspondence.
Email: f.neurochemistry@gmail.com
Russian Federation, Moscow

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