Myeloproliferative diseases and ischemic stroke

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Abstract

Myeloproliferative diseases (MPD) comprise a group of clonal pathology resulting from genetic alterations at a stem cell level. WHO (2008) divides MPD into several “classical” forms – polycythemia vera, essential thrombocytemia, and primary myelofibrosis. Haemorheologic and haemostatic disturbances have been widely accepted as a significant (in some cases – primary) cause of acute and/or chronic cerebrovascular disease. A pre-existing MPD may potentiate and accelerate the development of circulatory alterations, including those occurring in the brain tissue, leading to ischemic stroke. The present article comprises a literature review on this uncommon pathology, as well as a clinical presentation of a stroke case in a patient with underlying MPD (Vaquez’ disease).

About the authors

Marine M. Tanashyan

Research Center of Neurology

Email: angionev@gmail.com
ORCID iD: 0000-0002-5883-8119

D. Sci. (Med.), Prof., Corresponding member of RAS, Deputy Director for science, Head, 1st Neurological department

Russian Federation, Moscow

Polina I. Kuznetsova

Research Center of Neurology

Email: angionev@gmail.com
ORCID iD: 0000-0002-4626-6520

Cand. Sci. (Med.), neurologist, researcher, 1st Neurology department

Russian Federation, Moscow

Olga V. Lagoda

Research Center of Neurology

Author for correspondence.
Email: angionev@gmail.com
Russian Federation, Moscow

Alla A. Shabalina

Research Center of Neurology

Email: angionev@gmail.com
Russian Federation, Moscow

I. N. Subortseva

Research Center of Hematology, Ministry of Health

Email: angionev@gmail.com
Russian Federation, Moscow

A. L. Melikyan

Research Center of Hematology, Ministry of Health

Email: angionev@gmail.com
Russian Federation, Moscow

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Copyright (c) 2014 Tanashyan M.M., Kuznetsova P.I., Lagoda O.V., Shabalina A.A., Subortseva I.N., Melikyan A.L.

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