Myeloproliferative diseases and ischemic stroke
- Authors: Tanashyan M.M.1, Kuznetsova P.I.1, Lagoda O.V.1, Shabalina A.A.1, Subortseva I.N.2, Melikyan A.L.2
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Affiliations:
- Research Center of Neurology
- Research Center of Hematology, Ministry of Health
- Issue: Vol 8, No 2 (2014)
- Pages: 41-45
- Section: Reviews
- Submitted: 01.02.2017
- Published: 09.02.2017
- URL: https://annaly-nevrologii.com/journal/pathID/article/view/181
- DOI: https://doi.org/10.17816/psaic181
- ID: 181
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Abstract
Myeloproliferative diseases (MPD) comprise a group of clonal pathology resulting from genetic alterations at a stem cell level. WHO (2008) divides MPD into several “classical” forms – polycythemia vera, essential thrombocytemia, and primary myelofibrosis. Haemorheologic and haemostatic disturbances have been widely accepted as a significant (in some cases – primary) cause of acute and/or chronic cerebrovascular disease. A pre-existing MPD may potentiate and accelerate the development of circulatory alterations, including those occurring in the brain tissue, leading to ischemic stroke. The present article comprises a literature review on this uncommon pathology, as well as a clinical presentation of a stroke case in a patient with underlying MPD (Vaquez’ disease).
About the authors
Marine M. Tanashyan
Research Center of Neurology
Email: angionev@gmail.com
ORCID iD: 0000-0002-5883-8119
D. Sci. (Med.), Prof., Corresponding member of RAS, Deputy Director for science, Head, 1st Neurological department
Russian Federation, MoscowPolina I. Kuznetsova
Research Center of Neurology
Email: angionev@gmail.com
ORCID iD: 0000-0002-4626-6520
Cand. Sci. (Med.), neurologist, researcher, 1st Neurology department
Russian Federation, MoscowOlga V. Lagoda
Research Center of Neurology
Author for correspondence.
Email: angionev@gmail.com
Russian Federation, Moscow
Alla A. Shabalina
Research Center of Neurology
Email: angionev@gmail.com
Russian Federation, Moscow
I. N. Subortseva
Research Center of Hematology, Ministry of Health
Email: angionev@gmail.com
Russian Federation, Moscow
A. L. Melikyan
Research Center of Hematology, Ministry of Health
Email: angionev@gmail.com
Russian Federation, Moscow
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