Challenges with the differential diagnosis of progressive supranuclear palsy and Parkinson’s disease

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Progressive supranuclear palsy (PSP) is a severe old-age neurodegenerative disease that is characterized by pronounced clinical polymorphism and has different phenotypes. Practical differential diagnosis of PSP and Parkinson’s disease (PD) presents significant challenge, especially in onset of the disease. We report an atypical case of PSP characterized by symmetric levodopa-resistant parkinsonian syndrome, early postural instability, supranuclear oculomotor disorders (vertical gaze palsy), MR signs of midbrain atrophy, and a number of overlapping clinical symptoms similar with the manifestations of PD. A detailed algorithm of differential diagnosis of PSP and PD as well as a more adequate diagnostic formulation are proposed for this and similar cases of neurodegenerative pathology.

About the authors

R. V. Magzhanov

Bashkir State Medical University

Russian Federation, Ufa

Angelika I. Davletova

Bashkir State Medical University

Author for correspondence.
Russian Federation, Ufa

R. А. Ibatullin

Kuvatov Republican Clinical Hospital

Russian Federation, Ufa

V. F. Tunik

Kuvatov Republican Clinical Hospital

Russian Federation, Ufa

R. F. Idrisova

Kuvatov Republican Clinical Hospital

Russian Federation, Ufa

K. Z. Bakhtiyarova

Kuvatov Republican Clinical Hospital

Russian Federation, Ufa


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Copyright (c) 2016 Magzhanov R.V., Davletova A.I., Ibatullin R.А., Tunik V.F., Idrisova R.F., Bakhtiyarova K.Z.

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