Vascular aspects of multiple sclerosis: myth or reality?

Cover Page


Cite item

Full Text

Abstract

The article contains recent literature data concerning vascular aspects of multiple sclerosis (MS). The review provides a summary of three vascular abnormalities described in MS which include increased risk of developing ischaemic stroke, widespread decrease in cerebral perfusion and chronic cerebral venouse insufficiency with the assessment of the endovascular interventions efficacy.

About the authors

A. V. Peresedova

Research Center of Neurology

Email: kulikovasn@gmail.com
Россия, Moscow

S. N. Kulikova

Research Center of Neurology

Author for correspondence.
Email: kulikovasn@gmail.com
Россия, Moscow

I. A. Zavalishin

Research Center of Neurology

Email: kulikovasn@gmail.com
Россия, Moscow

References

  1. Кольяк Е.В. Цереброваскулярные нарушения и нейродегене-ративные изменения на поздних стадиях рассеянного склероза. Автореф. дисс. канд. мед. наук. Москва, 2009.
  2. Adhya S., Johnson G., Herbert J. et al. Pattern of hemodynamic impairment in multiple sclerosis: dynamic susceptibility contrast perfusion MR imaging at 3.0 T. Neuroimage. 2006; 33 (4): 1029–1035.
  3. Aksungar F.B., Topkaya A.E., Yildiz Z. et al. Coagulation status and biochemical and inflammatory markers in multiple sclerosis. J. Clin. Neurosci. 2008; 15 (4): 393–397.
  4. Allen N.B., Lichtman J.H., Cohen H.W. et al. Vascular disease among hospitalized multiple sclerosis patients. Neuroepidemiology 2008; 30: 234–238.
  5. Baracchini C., Perini P., Calabrese M. et al. No evidence of chronic cerebrospinal venous insufficiency at multiple sclerosis onset. Ann. Neurol. 2011; 69: 90–99.
  6. Baracchini C., Valdueza J.M., Del Sette M. et al. CCSVI and MS: a statement from the European Society of neurosonology and cerebral hemodynamics. J. Neurol. 2012; 259 (12): 2585–2589.
  7. Bartolomei I., Salvi F., Galeotti R. et al. Hemodynamic patterns of chronic cerebrospinal venous insufficiency in multiple sclerosis. Correlation with symptoms at onset and clinical course. Int. Angiol. 2010; 29: 183–188.
  8. Bastianello S., Romani A., Viselner G. et al. Chronic cerebrospinal venous insufficiency in multiple sclerosis: clinical correlates from a multicentre study. BMC Neurol. 2011; 11: 132.
  9. Bronnum-Hansen H., Koch-Henriksen N., Stenager E. Trends in survival and cause of death in Danish patients with multiple sclerosis. Brain. 2004; 127 (Pt 4): 844–850.
  10. Burton J.M., Alikhani K., Goyal M. et al. Complications in MS patients after CCSVI procedures abroad (Calgary, AB). Can. J. Neurol. Sci. 2011; 38 (5): 741–746.
  11. Christiansen C.F., Christensen S., Farkas D.K. et al. Risk of arterial cardiovascular diseases in patients with multiple sclerosis: a populationbased cohort study. Neuroepidemiology 2010; 35: 267–274.
  12. Craelius W., Migdal M.W., Luessenhop C.P. et al. Iron deposits surrounding multiple sclerosis plaques. Arch. Pathol. Lab. Med., 1982; 106 (8): 397–399.
  13. D’Haeseleer M., Cambron M., Vanopdenbosch L., De Keyser J. Vascular aspects of multiple sclerosis. Lancet Neurol. 2011; 10: 657–666.
  14. De Keyser J., Steen C., Mostert J.P., Koch M.W. Hypoperfusion of the cerebral white matter in multiple sclerosis: possible mechanisms and pathophysiological significance. J. Cereb. Blood Flow Metab. 2008; 28 (10): 1645–1651.
  15. Diaconu C.I., Conway D., Fox R.J., Rae-Grant A. Chronic cerebrospinal venous insufficiency as a cause of multiple sclerosis: controversy and reality. Curr, Treat. Options Cardiovasc. Med. 2012; 14 (2): 203–214.
  16. Doepp F., Paul F., Valdueza J.M. et al. No cerebrocervical venous congestion in patients with multiple sclerosis. Ann. Neurol., 2010; 68: 173–183.
  17. Dolic K., Weinstock-Guttman B., Marr K. et al. Risk factors for chronic cerebrospinal venous insufficiency (CCSVI) in a large cohort of volunteers. PLoS One 2011; 6 (11): e28062.
  18. Filippi M., Rocca M.A. The multiple sclerosis mystery: is there a vascular component? Lancet Neurol. 2011; 10 (7): 597–598.
  19. Haacke E.M., Garbern J., Miao Y. et al. Iron stores and cerebral veins in MS studied by susceptibility weighted imaging. Int. Angiol. 2010; 29: 149–157.
  20. Inglese M., Adhya S., Johnson G. et al. Perfusion magnetic resonance imaging correlates of neuropsychological impairment in multiple sclerosis. J. Cereb. Blood Flow Metab. 2008; 28:164–171.
  21. Khalil M., Teunissen C., Langkammer C. Iron and neurodegeneration in multiple sclerosis. Mult. Scler. Int. 2011; 2011: 606807.
  22. Koch-Henriksen N., Bronnum-Hansen H., Stenager E. Underlying cause of death in Danish patients with multiple sclerosis: results from the Danish Multiple Sclerosis Registry. J. Neurol. Neurosurg. Psychiatry 1998; 65 (1): 56–59.
  23. Laupacis A., Lillie E., Dueck A. et al. Association between chronic cerebrospinal venous insufficiency and multiple sclerosis: a meta-analysis. CMAJ, 2011; 183 (16): E1203–1212.
  24. Law M., Saindane A.M., Ge Y. et al. Microvascular abnormality in relapsing-remitting multiple sclerosis: perfusion MR imaging findings in normal-appearing white matter. Radiology. 2004; 231: 645–652.
  25. Lazzaro M.A., Zaidat OO., Mueller-Kronast N. et al. Endovascular therapy for chronic cerebrospinal venous insufficiency in multiple sclerosis. Front. Neurol. 2011; 2: 44.
  26. Mandato K.D., Hegener P.E., Siskin G.P. et al. Safety of endovascular treatment of chronic cerebrospinal venous insufficiency: a report of 240 patients with multiple sclerosis. J. Vasc. Interv. Radiol. 2012; 23 (1): 55–59.
  27. Marrie R.A., Rudick R., Horwitz R. et al. Vascular comorbidity is associated with more rapid disability progression in multiple sclerosis. Neurology, 2010; 74 (13): 1041–1047.
  28. Pache M., Kaiser H.J., Akhalbedashvili N. et al. Extraocular blood flow and endothelin-1 plasma levels in patients with multiple sclerosis. Eur. Neurol. 2003; 49 (3): 164–168.
  29. Patti F., Nicoletti A., Leone C. et al.Multiple sclerosis and CCSVI: a population-based case control study. PLoS One 2012; 7 (8): e41227.
  30. Reekers J.A., Lee M.J., Belli A.M., Barkhof F. Cardiovascular and Interventional Radiological Society of Europe commentary on the treatment of chronic cerebrospinal venous insufficiency. Cardiovasc. Intervent. Radiol. 2011; 34 (1): 1–2.
  31. Russo C., Morabito F., Luise F. et al.Hyperhomocysteinemia is associated with cognitive impairment in multiple sclerosis. J. Neurol. 2008; 255: 64–69.
  32. Sahin S., Aksungar F.B., Topkaya A.E. et al. Increased plasma homocysteine levels in multiple sclerosis. Mult. Scler. 2007; 13: 945–946.
  33. Saindane A.M., Law M., Ge Y. et al. Correlation of diffusion tensor and dynamic perfusion MR imaging metrics in normal-appearing corpus callosum: support for primary hypoperfusion in multiple sclerosis. AJNR Am. J. Neuroradiol. 2007; 28 (4): 767–772.
  34. Sheremata W.A., Jy W., Horstman L.L. et al. Evidence of platelet activation in multiple sclerosis. J. Neuroinflamation. 2008; 5: 27.
  35. Simka M. Blood brain barrier compromise with endothelial inflammation may lead to autoimmune loss of myelin during multiple sclerosis. Curr. Neurovasc. Res. 2009; 6 (2): 132–139.
  36. Singh A.V., Zamboni P. Anomalous venous blood flow and iron deposition in multiple sclerosis. J. Cereb. Blood Flow Metab. 2009; 29: 1867–1878.
  37. Talbert D.G. Raised venous pressure as a factor in multiple sclerosis. Med. Hypotheses 2008; 70 (6): 1112–1117.
  38. Varga A.W., Johnson G., Babb J.S. White matter hemodynamic abnormalities precede sub-cortical gray matter changes in multiple sclerosis. J. Neurol. Sci. 2009; 282: 28–33.
  39. Waschbisch A., Manzel A., Linker R.A., Lee D.H. Vascular pathology in multiple sclerosis: mind boosting or myth busting? Exp. Transl. Stroke Med. 2011; 3 (1): 7.
  40. Wattjes M.P., van Oosten B.W., de Graaf W.L. et al. No association of abnormal cranial venous drainage with multiple sclerosis: a magnetic resonance venography and flow-quantification study. J. Neurol. Neurosurg. Psychiatr., 2011; 82: 429–435.
  41. Weinstock-Guttman B., Ramanathan M., Marr K. et al. Clinical correlates of chronic cerebrospinal venous insufficiency in multiple sclerosis. BMC Neurol. 2012; 12: 26.
  42. Yamout B., Herlopian A., Issa Z. et al. Extracranial venous stenosis is an unlikely cause of multiple sclerosis. Mult. Scler. 2010; 16: 1341–1348.
  43. Zamboni P. The big idea – iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis. J. R. Soc. Med. 2006; 99: 589–593.
  44. Zamboni P., Galeotti R., Menegatti E. et al. Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 2009b; 80: 392–399.
  45. Zamboni P., Menegatti E., Weinstock-Guttman B. et al. Hypoperfusion of brain parenchyma is associated with the severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis: a cross-sectional preliminary report. BMC Med 2011; 9: 22.
  46. Zivadinov R., Marr K., Cutter G. et al. Prevalence, sensitivity, and specificity of chronic cerebrospinal venous insufficiency in MS. Neurology, 2011; 77 (2): 138–144.
  47. Zivadinov R., Schirda C., Dwyer M.G. et al. Chronic cerebrospinal venous insufficiency and iron deposition on susceptibility-weighted imaging in patients with multiple sclerosis: a pilot case-control study. Int. Angiol. 2010; 29: 158–175.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2013 Peresedova A.V., Kulikova S.N., Zavalishin I.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77-83204 от 12.05.2022.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies