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The Parkinson’s disease (PD) pathology is not limited by degeneration of the nigrostriatal dopaminergic system, but includes also wide involvement of different regions of cerebral cortex. The aim of this study was the identification of differences in the brain cortical thickness in patients with early and advanced PD with the use of MRI morphometry. Sixty seven PD patients with Hoehn-Yahr 2 and 3 stages were examined. All patients underwent MRI with subsequent post-processing and receiving of cortical thickness parameters in different brain regions. Significant differences in the visual cortex, the cingulated and fusiform gyri and the frontopolar zone of a dominant hemisphere, and the Brodmann’s areas 1, 2, 3 and 4 of a non-dominant hemisphere were obtained. These data allow revealing relationships between non-motor manifestations of PD and degeneration of certain cortical regions of the brain.
Cortical cerebral atrophy in patients with Parkinson’s disease: new trends in the diagnostics in vivo
- Authors: Trufanov A.G.1, Litvinenko I.V.1, Odinak M.M.1, Voronkov L.V.2, Khaimov D.A.2, Efimzev A.Y.2, Fokin V.A.2
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Affiliations:
- S.M. Kirov Military Medical Academy
- Military Medical Academy named after S.M. Kirov
- Issue: Vol 7, No 3 (2013)
- Pages: 37-41
- Section: Original articles
- Submitted: 02.02.2017
- Published: 09.02.2017
- URL: https://annaly-nevrologii.com/journal/pathID/article/view/228
- DOI: https://doi.org/10.17816/psaic228
- ID: 228
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About the authors
Artem G. Trufanov
S.M. Kirov Military Medical Academy
Author for correspondence.
Email: trufanovart@gmail.com
Россия, St. Petersburg
Igor V. Litvinenko
S.M. Kirov Military Medical Academy
Email: trufanovart@gmail.com
Россия, St. Petersburg
Miroslav M. Odinak
S.M. Kirov Military Medical Academy
Email: trufanovart@gmail.com
Россия, St. Petersburg
L. V. Voronkov
Military Medical Academy named after S.M. Kirov
Email: trufanovart@gmail.com
Россия, St.-Petersburg
D. A. Khaimov
Military Medical Academy named after S.M. Kirov
Email: trufanovart@gmail.com
Россия, St.-Petersburg
A. Yu. Efimzev
Military Medical Academy named after S.M. Kirov
Email: trufanovart@gmail.com
Россия, St.-Petersburg
V. A. Fokin
Military Medical Academy named after S.M. Kirov
Email: trufanovart@gmail.com
Россия, St.-Petersburg
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