Cortical cerebral atrophy in patients with Parkinson’s disease: new trends in the diagnostics in vivo

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Abstract

The Parkinson’s disease (PD) pathology is not limited by degeneration of the nigrostriatal dopaminergic system, but includes also wide involvement of different regions of cerebral cortex. The aim of this study was the identification of differences in the brain cortical thickness in patients with early and advanced PD with the use of MRI morphometry. Sixty seven PD patients with Hoehn-Yahr 2 and 3 stages were examined. All patients underwent MRI with subsequent post-processing and receiving of cortical thickness parameters in different brain regions. Significant differences in the visual cortex, the cingulated and fusiform gyri and the frontopolar zone of a dominant hemisphere, and the  Brodmann’s areas 1, 2, 3 and 4 of a non-dominant hemisphere were obtained. These data allow revealing relationships between non-motor manifestations of PD and degeneration of certain cortical regions of the brain.

 

About the authors

Artem G. Trufanov

S.M. Kirov Military Medical Academy

Author for correspondence.
Email: trufanovart@gmail.com
Russian Federation, St. Petersburg

Igor V. Litvinenko

S.M. Kirov Military Medical Academy

Email: trufanovart@gmail.com
Russian Federation, St. Petersburg

Miroslav M. Odinak

S.M. Kirov Military Medical Academy

Email: trufanovart@gmail.com
Russian Federation, St. Petersburg

L. V. Voronkov

Military Medical Academy named after S.M. Kirov

Email: trufanovart@gmail.com
Russian Federation, St.-Petersburg

D. A. Khaimov

Military Medical Academy named after S.M. Kirov

Email: trufanovart@gmail.com
Russian Federation, St.-Petersburg

A. Yu. Efimzev

Military Medical Academy named after S.M. Kirov

Email: trufanovart@gmail.com
Russian Federation, St.-Petersburg

V. A. Fokin

Military Medical Academy named after S.M. Kirov

Email: trufanovart@gmail.com
Russian Federation, St.-Petersburg

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Copyright (c) 2013 Trufanov A.G., Litvinenko I.V., Odinak M.M., Voronkov L.V., Khaimov D.A., Efimzev A.Y., Fokin V.A.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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